Clinical_Rounds_in_Endocrinology_Volume_II_-_Pediatric_Endocrinology

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a b

Fig. 1.16 (a) A 12-year-old child with short stature, obesity, and (b) moon facies due to Cushing’s
syndrome. Note lack of striae and bruise in the child

58. What are the causes of childhood Cushing’s syndrome with normal growth
    velocity?
    Normal growth velocity in a child with Cushing’s syndrome can occur in the
    presence of mild hypercortisolemia [as associated with primary pigmented
    nodular adrenal hyperplasia (PPNAD)], intermittent hypercortisolemia (cyclical
    Cushing’s syndrome), and cortisol and androgen co-secreting adrenal tumors.
    In addition, children with Cushing’s syndrome due to McCune–Albright

1 Disorders of Growth and Development: Clinical Perspectives