Tissue Engineering And Nanotheranostics

(Steven Felgate) #1
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“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics

Chapter 1


Engineering Approaches


for Creating Skeletal Muscle


Caleb Vogt, Mitchell Tahtinen and Feng Zhao


Department of Biomedical Engineering


Michigan Technological University


Houghton, MI 49931, USA


Abstract: Engineered skeletal muscle grafts have made great
progress during the past decades, benefiting from a growing
understanding of mechanobiology and stem cell differentiation.
Current techniques are widely varied, ranging from in vitro
methods following the classical tissue engineering paradigm to
in situ approaches such as host cell recruitment. In different ways,
all of these try to supply mechanical toughness while providing
the necessary signals for differentiation and maturation of the
engineered skeletal muscle.

Keywords: Skeletal muscle, volumetric muscle loss, myogenesis,
muscle regeneration, stem cell engineering.

1. Clinical Need for Skeletal Muscle


The biomedical research community has long held an interest in engi-


neering replacements for skeletal muscles. Diseases and injuries that


result in muscle loss can lead to significant weakness and deformity,


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