b2815 Tissue Engineering and Nanotheranostics “9.61x6.69”118 Tissue Engineering and Nanotheranostics
Janus particles, the terpolymers need to have two outer soluble end
blocks, A and C, and an inner insoluble block, B. The simplest
method to understand the self-assembly processes is given below
in Fig. 11.19,20,69
Though the fabrication of Janus-colloidal particles has been evolv-
ing, the applications are still in infancy. Janus particles exhibit a num-
ber of distinctive properties in comparison to single domain particles
due to their asymmetric structure and functionalization. Here, it is
possible to alter their magnetic, catalytic, amphiphilic, electrical,
Fig. 11. Schematic illustration of the self-assembly mechanism: (a) Formation of
Janus nanostructure by a self-assembly process of multicompartment micelles, (b) TEM
images of “clover” multicompartment micelles and corresponding Janus particles
(OsO4 staining: PS gray, PB black, and PMMA is not visible due to electron beam
degradation), and (c) schematic clustering of asymmetric JPs in dependence of the
corona size in water and chloroform (PS is gray and PB is black). Reprinted with per-
mission from Ref. 19.