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“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics

Chapter 6

Plasmonic Nanoparticles Application

in Biosensor and Bioimaging

Mengmeng Liu

The Institute of Nanomedicine East Hospital

Tongji University School of Medicine

Shanghai, P. R. China

Abstract: Plasmonic nanoparticles hold great promising potential in

applications for biosensor and bioimaging due to their unique optical

property, tunable physical morphology, and surface characteristics.

They extinct incident light with a certain wavelength efficiency,

caused by coherent oscillation of the conduction electrons on their

surface at nanoscale, and their strong interaction is known as localized

surface plasmon resonance (LSPR). Meanwhile, their LSPR spectral,

highly associated with their size, shape, and microenvironment sur­

rounding them, provide us a conventional way to investigate the

biomolecules’ interaction, such as cell protein expression and DNA

hybridization, and map the LSPR probe at the single molecule level.

Additionally, plasmonic nanoparticle­based energy transfer, surface­

enhanced Raman scattering, and photothermal therapy further

enlarge its application in analyzing biomolecule and killing tumor

in vivo.