Tissue Engineering And Nanotheranostics

“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics

Plasmonic Nanoparticles Application in Biosensor and Bioimaging 175

DFM when the binding event of nanoparticles was carefully investi­

gated, and the steps showed good agreement with a number of the

additional particles observed by SEM (Fig. 5). This fact confirmed the

capability of single­binding detection by DFM.^135 Similar to Lee’s, a

dimer sensor system was designed to detect miR210. In this system,

Fig. 4. (A) Principle of nanoplasmonic imaging of LFPs and identification of
cocaine in LFPs by DFM. (B) Magnified dark­field images of LFPs containing dif­
ferent loadings of cocaine. (a) 0 g, (b) 1.5 × 10 –7 g, (c) 3 × 10 –7 g, (d) 7.5 × 10 –7 g,
(e) 1.5 × 10 –6 g, (f) 3 × 10 –6 g, (g) 1.5 × 10 –5 g, and (h) 3 × 10 –5 g. Figure modified
with permission from Ref. 109. Copyright 2014, Elsevier B.V.