Tissue Engineering And Nanotheranostics

“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics

Plasmonic Nanoparticles Application in Biosensor and Bioimaging 181

molecules adsorbed on their surface, energy transferred by PRET

induces a wavelength­dependent quenching in the scattering pro­

file.^166 Due to the strong scattering intensity in the visible region,

AuNPs are considered to be perfect material for the studying of

PRET. For instance, As the amine complex of [Cu(TMSen)]^2 has

optical absorption peaks in the visible range (around 550 nm), AuNPs

with 50 nm in diameter, of which scattering peak lay around 550 nm,

was used to form nanoplasmonic probe, this nanoplasmonic probe is

shown in Fig. 6. This probe with ethylenediamine moiety modified

Fig. 6. Plasmonic resonance energy transfer­based metal ion sensing (PRET–MIS).
(a) When the transition metal ion (blue) binds with the matching ligand (red), owing
to the new absorption band, transferred to the metal–ligand complex. (b) There is no
spectral overlap between ligands without the metal ion and the GNP (left). When the
electronic absorption frequency of the metal–ligand complex matches with the
Rayleigh scattering frequency, the selective energy transfer is induced by this spectral
overlap (middle) and the distinguishable resonant quenching on the resonant
Rayleigh scattering spectrum is observed (right). Reprinted with permission from
Ref. 161 Copyright 2009, NPG.