Tissue Engineering And Nanotheranostics

“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics

Characterization of Biomaterial Patches as Fetal Surgery Implants 33

Zogbi and coworkers compared the shrinkage of heavyweight PP

(HW–PP) and lightweight PP (LW–PP) meshes after 7, 28 and

90 days of fixation on abdominal surfaces of 25 Wistar rats (Fig. 2).

A HW–PP mesh (Marlex®) measuring 95 g/m^2 was implanted on the

right side of each rat and a LW–PP mesh (Parietene®) on the left

side.^11 The statistical analysis was carried out using the Statistical

Package for Social Sciences (SPSS) 18.0 and shrinkage was computed

using the Kruskal–Wallis test, with a 95% level of significance (P ≤

0.05). The significance for each mesh shrinkage at 7, 28 and 90 days

was 0.647, 0.020 and 0.013, respectively for HW–PP mesh, and

0.040, 0.014 and 0.001, respectively for LW–PP mesh.^11

This report by Zogbi and coworkers hypothesize that less HW–

PP mesh shrinkage at 90 days (2.5%) than at 28 days (2.7%) is due to

the progressive weight gain of the rats, and links the mesh weight

with the shrinkage and thus the inflammatory response.^11

An investigation by Jacob and coworkers distinguished the shrink-

age of a lightweight large pore PP mesh (Optilene® LP) and medium-

weight large pore knitted PTFE mesh (GORE® INFINIT® mesh),

after porcine implantation (Fig. 3). An analysis of variance was

performed with a statistical significance in p-values below 0.05, using

a SPSS 14.0 statistics program. Measurements after 3 months of

Fig. 2. Median mesh shrinkage vs. time points for LW–PP and HW–PP meshes.^11