Tissue Engineering And Nanotheranostics

“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics

Characterization of Biomaterial Patches as Fetal Surgery Implants 39

meshes in both directions, except for Ultrapro® where it declined

after an initial rise (Fig. 7).^18

From the results, Velayudhan and Martin concluded that all

meshes strain hardened and underwent permanent plastic deforma-

tion, which can lead to complications for long-term implantations.^18

The authors pointed out that lower secant moduli of meshes at 37°C

in PBS than that at 23°C in air was due to higher polymer chain

mobility at elevated temperatures.^18 This claim can be further consoli-

dated by providing glass transition temperature values of the polymers

used, and debating whether a temperature of 37°C would affect the

chain mobility. Though the test conditions in this article better mimic

Fig. 7. Variation of secant modulus of various meshes in (a) warp and (b) weft direc-
tions with the number of cycles tested in PBS at 37°C.^18

120 100 80 60 40 20 0

120

140

100 80 60 40 20 0

0 20000 4000 No. of cycles, N

No. of cycles, N

Secant modulus, N/mm

60000 80000 100000

0 20000

Fractured

40000 60000 80000 100000

Prolene Vypro Vypro II Utrapro

(a)

(b)