reverse-phase protein microarray (RPPA) platform for the analysis of clinical
samples (LCM-RPPA). The LCM-RPPA study was used for the evaluation of the
changes of phosphorylation status of key kinases in human colorectal carcinomas^22
Fig. 3 Summary of the personal omics profiling that reveals dynamic molecular and medical
phenotype of one investigated individual (according to Chen et al. 2012 ). (a) Time course
summary for the monitoring for total 726 days, during which there were two viral infections
(seeredandgreen bar). Theblackindicates life style change: ( 1 ) increased exercise, ( 2 ) ingested
acetylsalicylic acid and ibuprofen tablets, ( 3 ) reduced sugar intake. (b) Integrative omics profile
experimental design indicating tissues and analyses involved in this study. (c) Circos plot
summarizing the integrative omics profile (see Krzywinski et al. 2009 ). (reproduced from Chen
et al. 2012 , with permission)
(^22) Silvestri et al. ( 2013 ), pp. 309–316.
186 D. Josic ́and U. Andjelkovic ́