microwell platform was used by Lepperdinger research group to culture bone-
marrow-derived stem cells for several weeks [ 14 ]. The authors reported that the
developed LoC platform controls the quality of stem cells in medical cell produc-
tion platform. Thus, significant attention is given to stem cell research owing to
high therapeutic potential and their use asin vitromodels for drug screening and
understanding the developmental mechanisms.
Fig. 8.1 (A) HDF microfluidic chip for sorting of particles and hMSCs where the number of
branch channels is 55 and the total length of the main channel is 16 mm [ 12 ]. (B)(a) schematic of
the LEPD enclosed within a Petri dish, (b) an optical image of the LEPD, made of PDMS, with
three inlets and three outlets connected to microchannels, and (c) and (d) magnified views of area
A in the schematic drawing depicting an adhered cell covering a micropore, and the mechanism of
delivery of molecules by localized electroporation, respectively [ 13 ]
8 Biological Applications of Microfluidics System 195