experiences fluid flow and supports the growth of microbial flora without
compromising human cell viability [ 34 , 36 ]. The GoC’microdevice composed of
two MF channels that are separated by a flexible porous membrane coated with
Fig. 8.5 (A) Structure and design of the developedμBBB. (i) TheμBBB system comprises two
perpendicular flow channels. (ii) The fully fabricatedμBBB chip. (iii) Close-up view [ 32 ]. (B)(i)
and (ii) Design of a MF device mimicking the structure of a hepatic cord. (iii) SEM image of the
device [ 33 ]. (C) A schematic of the GoC device. (i) A schematic of the gut-on-a-chip device
showing the flexible porous ECM-coated membrane lined by gut epithelial cells cross horizontally
through the middle of the central microchannel, and full height vacuum chambers on both sides.
(ii) A photographic image of the device. (iii) A cross-sectional view of the top and bottom channels
(both 150μm high) of the gut-on-a-chip; square inset shows a top view of a portion of the porous
membrane [ 34 ]
8 Biological Applications of Microfluidics System 203