Table 8.2List of different organ on chip devices with few fabrication and operation parametersOrganon chipType of cellsculturedOrgan level specific functionmimickedPlatformRate of fluidflowShear stressReferencesHeartCardiac myocytes Contractility and tissuestructureMascular thin film based singlechannel fluidic chip with metallicbase1 mL min^1–[46]LiverHepatocytes,hepatic stellatecellsImproved cell-cell interac-tion, controlled fluid flowrateBichambered MF device withfluid flow controlled by osmoticpump94.7–304.7μLper 12 h–[47]Kidney Primary epithelialcellsLow shear stress conditions,tubular morphologyMF device consisting of twocompartments separated byporous polyester membrane0.2 dyne cm^2[^48]LungAlveolar epithe-lial cells, pulmo-nary endothelialcellsPressure driven stretchingoccurring in alveolar capil-lary interface duringbreathingFlow stretch strip having twoclosely apposed microchannelsseparated by a 10μm porousPDMS membrane20μLh^1–[31]Intestine Intestinal epithe-lial cellsPeristaltic movements ofintestine, microbial growthin stomachMF device consisting of twocompartments separated byporous polyester membrane10–100μLh^10.002–0.08 dyne cm^2[^34]BrainBrain endothelialcellsBlood brain barrier functionof brainBilayered membrane based MFdevice2.5 mL h^10.58 Pa[^49]206 S. Solanki and C.M. Pandey