Treatment of Inflammatory Bowel Disease with Biologics

215

5

4.5

4

3.5

2.5

3

SIR

2

1

0

1978–1987 1988–1997 1998–2009

1.5

0.5

Intestinal Any Cancer

Hematological

5

4.5

4

3.5

2.5

3

SIR

2

1

0

1978 – 1987 1988 – 1997 1998 – 2009

1.5

0.5

Intestinal Any Cancer

Hematological

a

b

Fig. 13.1 (a) Relative risk by decade, Crohn’s disease. (b) Relative risk by decade, ulcerative
colitis

13 Tumor Necrosis Factor-Alpha Inhibitors and Risks of Malignancy