Treatment of Inflammatory Bowel Disease with Biologics

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  1. Feagan B. Update on tofacitinib for inflammatory bowel disease. Gastroenterol Hepatol (N Y).
    2016;12:572–4.

  2. Sandborn WJ, Sands BE, D'Haens G, et  al. Efficacy and safety of oral tofacitinib as induc-
    tion therapy in patients with moderate-to-severe ulcerative colitis: results from 2 phase 3 ran-
    domised controlled trials. J Crohns Colitis. 2016;10:S15-S.

  3. Sandborn W, Sands B, Danese S, et al. Efficacy and safety of oral tofacitinib as maintenance
    therapy in patients with moderate to severe ulcerative colitis: results from a phase 3 randomised
    controlled trial. J Crohns Colitis. 2017;10:S15-S.

  4. Panes J, Sandborn WJ, Schreiber S, et  al. Tofacitinib for induction and maintenance ther-
    apy of Crohn’s disease: results of two phase IIb randomised placebo-controlled trials. Gut.
    2017;66(6):1049–59.

  5. Vermeire S, Schreiber S, Petryka R, et  al. Clinical remission in patients with moderate-to-
    severe Crohn’s disease treated with filgotinib (the FITZROY study): results from a phase 2,
    double-blind, randomised, placebo-controlled trial. Lancet. 2017;389:266–75.

  6. Ardizzone S, Bevivino G, Monteleone G.  Mongersen, an oral Smad7 antisense oligonucle-
    otide, in patients with active Crohn’s disease. Therap Adv Gastroenterol. 2016;9:527–32.

  7. Monteleone G, Neurath MF, Ardizzone S, et al. Mongersen, an oral SMAD7 antisense oligo-
    nucleotide, and Crohn’s disease. N Engl J Med. 2015;372:1104–13.

  8. Monteleone G, Kumberova A, Croft NM, McKenzie C, Steer HW, MacDonald TT. Blocking
    Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J  Clin Invest.
    2001;108:601–9.

  9. Vermeire S. Oral SMAD7 antisense drug for Crohn’s disease. N Engl J Med. 2015;372:1166–7.


17 Novel Agents in Inflammatory Bowel Disease

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