vii1 Mechanism of Action and Pharmacokinetics of Biologics.......... 1
Alan C. Moss
2 Antitumor Necrosis Factor Agents in Ulcerative Colitis............ 13
Kindra Clark-Snustad, Ives Hot, and Scott Lee
3 Antitumor Necrosis Factor Agents in Crohn’s Disease............. 33
Byron P. Vaughn
4 Anti-TNF Therapy for Treatment of Extraintestinal
Manifestations of Inflammatory Bowel Disease................... 49
David I. Fudman and Sarah N. Flier
5 Use of Biologics in the Postoperative Management
of Crohn’s Disease........................................... 59
Benjamin H. Click and Miguel Regueiro
6 Biologics in Pregnancy and Breastfeeding....................... 81
Jill K.J. Gaidos and Sunanda V. Kane
7 Concomitant Use of Immunosuppressive Therapy
with Tumor Necrosis Factor (TNF) Antagonists
in Inflammatory Bowel Disease................................ 101
Parambir S. Dulai and Corey A. Siegel
8 Therapeutic Drug Monitoring of Biologic Agents................. 113
Frank I. Scott and Mark T. Osterman
9 Use of Biologics in Crohn’s Disease and Ulcerative
Colitis Prior to Surgery and Perioperative Risks.................. 129
Afrin Kamal and Bret Lashner
10 Cessation of Biologics: Can It Be Done?......................... 141
Hang Hock Shim and Cynthia H. Seow