Fig. 4A typical schematic workflow of clonal structure inference and visualization based on single-cell DNA
sequencing. (a) The brief processed of single-cell DNA sequencing. (b) Clonal structure inferences, including
clustering the data, predicting clonal genotypes, and inferring the prevalence of clones. (c) Visualize the clonal
structure with fishplot or evolution tree (a toy example).aandbwere adapted from ref.167;cwas courtesy of
Dr. Florian Markowetz
Applications of Single-Cell Sequencing for Multiomics 361