Medical Therapy for Stifle Osteoarthritis 341drug-induced adverse effects in dogs. J Vet Intern
Med 2013;27:1011–1019.
Moreau M, Dupuis J, Bonneau NH,et al. Clinical eval-
uation of a nutraceutical, carprofen and meloxicam
for the treatment of dogs with osteoarthritis. Vet
Rec 2003;152:323–329.
Moreau M, Troncy E, Del Castillo JR,et al. Effects of
feeding a high omega-3 fatty acids diet in dogs with
naturally occurring osteoarthritis. J Anim Physiol
Anim Nutr (Berl) 2013;97:830–837.
Murase A, Okumura T, Sakakibara A,et al.Effectof
prostanoid EP4 receptor antagonist, CJ-042,794, in
rat models of pain and inflammation. Eur J Phar-
macol 2008;580:116–121.
Nakao K, Murase A, Ohshiro H,et al. CJ-023,423,
a novel, potent and selective prostaglandin EP4
receptor antagonist with antihyperalgesic proper-
ties. J Pharmacol Exp Ther 2007;322: 686–694.
Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid
receptors: structure, properties and functions.
Physiol Rev 1999;79:1193–1226.
Neil KM, Caron JP, Orth MW. The role of glu-
cosamine and chondroitin sulfate in treatment for
and prevention of osteoarthritis in animals. J Am
Vet Med Assoc 2005;226:1079–1088.
Otero M, Lago R, Gomez R,et al. Leptin: a metabolic
hormone that functions like a proinflammatory
adipokine. Drug News Perspect 2006;19:21–26.
Raffa RB, Friderichs E, Reimann W,et al.Opioid
and nonopioid components independently con-
tribute to the mechanism of action of tramadol, an
‘atypical’ opioid analgesic. J Pharmacol Exp Ther
1992;260:275–285.
Rausch-Derra L, Huebner M, Wofford J, et al.
Prospective, randomized, masked, placebo-
controlled multisite clinical study of grapiprant,
an EP4 prostaglandin receptor antagonist (PRA),
in dogs with osteoarthritis. J Vet Intern Med
2016;30:756–763.
Rausch-Derra LC, Huebner M, Rhodes L. Evaluation
of the safety of long-term, daily oral administra-
tion of grapiprant, a novel drug for treatment of
osteoarthritic pain and inflammation, in healthy
dogs. Am J Vet Res 2015;76:853–859.
Rialland P, Bichot S, Lussier B,et al.Effectofa
diet enriched with green-lipped mussel on pain
behavior and functioning in dogs with clinical
osteoarthritis. Can J Vet Res 2013;77:66–74.
Roush JK, Cross AR, Renberg WC,et al. Evaluation of
the effects of dietary supplementation with fish oil
omega-3 fatty acids on weight bearing in dogs with
osteoarthritis. J Am Vet Med Assoc 2010;236:67–73.
Ryan WG, Moldave K, Carithers D. Switching
NSAIDs in practice: insights from the Previcox
(firocoxib) experience trial. Vet Ther 2007;8:263–
271.
Schiavinato A, Lini E, Guidolin D,et al. Intraar-
ticular sodium hyaluronate injections in the
Pond-Nuki experimental model of osteoarthritis
in dogs. II. Morphological findings. Clin Orthop
Relat Res 1989;241:286–299.
Sevalla K, Todhunter RJ, Verneir-Singer M,et al.Effect
of polysulfated glycosaminoglycan on DNA con-
tent and proteoglycan metabolism in normal and
osteoarthritic canine articular cartilage explants.
Vet Surg 2000;29:407–414.
Smith G, Jr, Myers SL, Brandt KD,et al.Effect
of intraarticular hyaluronan injection on verti-
cal ground reaction force and progression of
osteoarthritis after anterior cruciate ligament tran-
section. J Rheumatol 2005;32:325–334.
Smith GK, Paster ER, Powers MY, et al.Life-
long diet restriction and radiographic evidence of
osteoarthritis of the hip joint in dogs. J Am Vet Med
Assoc 2006;229:690–693.
Smith GN, Jr, Mickler EA, Myers SL,et al.Effect
of intraarticular hyaluronan injection on synovial
fluid hyaluronan in the early stage of canine post-
traumatic osteoarthritis. J Rheumatol 2001;28:1341–
1346.
Souza MH, de Lima OM, Jr, Zamuner SR,et al.Gastri-
tis increases resistance to aspirin-induced mucosal
injury via COX-2-mediated lipoxin synthesis. Am
J Physiol Gastrointest Liver Physiol 2003;285:54–
61.
Todhunter RJ, Lust G. Polysulfated glycosaminogly-
can in the treatment of osteoarthritis. J Am Vet Med
Assoc 1994;8:1245–1251.
Vandeweerd JM, Coisnon C, Clegg P,et al. System-
atic review of efficacy of nutraceuticals to allevi-
ate clinical signs of osteoarthritis. J Vet Intern Med
2012;26:448–456.
Vasseur PB, Berry CR. Progression of stifle
osteoarthrosis following reconstruction of the
cranial cruciate ligament in 21 dogs. J Am Anim
Hosp Assoc 1992;28:129–136.
Vilar JM, Morales M, Santana A,et al. Controlled,
blinded force platform analysis of the effect
of intraarticular injection of autologous adipose-
derived mesenchymal stem cells associated to
PRGF-Endoret in osteoarthritic dogs. BMC Vet Res
2013;9:131.
Vilar JM, Batista M, Morales M,et al. Assessment
of the effect of intra-articular injection of autolo-
gous adipose-derived mesenchymal stem cells in
osteoarthritic dogs using a double blinded force
platform analysis. BMC Vet Res 2014;10:143.
Wanstrath AW, Hettlich BF, Su L,et al. Evaluation
of a single intra-articular injection of autologous
protein solution for treatment of osteoarthritis in a
canine population. Vet Surg 2016;45:764–774.
Webster RP, Anderson GI, Gearing DP. Canine Brief
Pain Inventory scores for dogs with osteoarthritis
before and after administration of a monoclonal
antibody against nerve growth factor. Am J Vet Res
2014;75:532–535.