Advances in the Canine Cranial Cruciate Ligament, 2nd edition

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Regenerative Medicine and Cranial Cruciate Ligament Repair 377

Murray MM. Current status and potential of primary
ACL repair. Clin Sports Med 2009;28:51–61.
Murray MM, Fleming BC. Use of a bioactive scaf-
fold to stimulate anterior cruciate ligament healing
also minimizes posttraumatic osteoarthritis after
surgery. Am J Sports Med 2013;41:1762–1770.
Murray MM, Spector M. Fibroblast distribution in the
anteromedial bundle of the human anterior cruci-
ate ligament: the presence of alpha-smooth muscle
actin-positive cells. J Orthop Res 1999;17:18–27.
Murray MM, Spector M. The migration of cells
from the ruptured human anterior cruciate liga-
ment into collagen-glycosaminoglycan regenera-
tion templatesin vitro. Biomaterials 2001;22:2393–
2402.
Murray MM, Spindler KP. Anterior cruciate liga-
ment healing and repair. Sports Med Arthrosc Rev
2005;13:151–155.
Murray MM, Martin SD, Martin TL,et al.Histologi-
cal changes in the human anterior cruciate ligament
after rupture. J Bone Joint Surg Am 2000a;82:1387–
1397.
Murray MM, Martin SD, Spector M. Migration
of cells from human anterior cruciate ligament
explants into collagen-glycosaminoglycan scaf-
folds. J Orthop Res 2000b;18:557–564.
Murray MM, Bennett R, Zhang X,et al.Cell out-
growth from the human ACLin vitro: regional vari-
ation and response to TGF-beta1. J Orthop Res
2002;20:875–880.
Murray MM, Forsythe B, Chen F,et al.The effect
of thrombin on ACL fibroblast interactions
with collagen hydrogels. J Orthop Res 2006;24:
508–515.
Murray MM, Palmer M, Abreu E,et al.Platelet-
rich plasma alone is not sufficient to enhance
suture repair of the ACL in skeletally immature
animals: anin vivostudy. J Orthop Res 2009;27:
639–645.
Murray MM, Spindler KP, Ballard P,et al.Enhanced
histologic repair in a central wound in the ante-
rior cruciate ligament with a collagen-platelet-rich
plasma scaffold. J Orthop Res 2007a;25:1007–1017.
Murray MM, Spindler KP, Abreu E,et al.Collagen-
platelet rich plasma hydrogel enhances primary
repair of the porcine anterior cruciate ligament.
J Orthop Res 2007b;25:81–91.


Proffen BL, Vavken P, Haslauer CM,et al.Addition
of autologous mesenchymal stem cells to whole
blood for bioenhanced ACL repair has no benefit in
the porcine model. Am J Sports Med 2015;43:320–
330.
Proffen BL, Sieker JT, Murray MM,et al.Extracellu-
lar matrix-blood composite injection reduces post-
traumatic osteoarthritis after anterior cruciate lig-
ament injury in the rat. J Orthop Res 2016;34:995–
1003.
Rayward RM, Thomson DG, Davies JV,et al.Pro-
gression of osteoarthritis following TPLO surgery:
a prospective radiographic study of 40 dogs. J Small
Anim Pract 2004;45:92–97.
Rosc D, Powierza W, Zastawna E,et al.Post-traumatic
plasminogenesis in intraarticular exudate in the
knee joint. Med Sci Monit 2002;8:CR371–CR378.
Sieker JT, Ayturk UM, Proffen BL,et al.Immedi-
ate administration of intraarticular triamcinolone
acetonide after joint injury modulates molecular
outcomes associated with early synovitis. Arthritis
Rheumatol 2016;68:1637–1647.
Slocum B, Slocum TD. Tibial plateau leveling
osteotomy for repair of cranial cruciate ligament
rupture in the canine. Vet Clin North Am Small
Anim Pract 1993;23:777–795.
Spindler KP, Murray MM, Carey JL,et al.The use of
platelets to affect functional healing of an anterior
cruciate ligament (ACL) autograft in a caprine ACL
reconstruction model. J Orthop Res 2009;27:631–
638.
Vavken P, Saad Fa, Murray MM. Age dependence of
expression of growth factors in porcine ACLfibrob-
lasts. J Orthop Res 2010;28:1107–1112.
Vavken P, Fleming BC, Mastrangelo AN,et al.Biome-
chanical outcomes after bioenhanced anterior cru-
ciate ligament repair and anterior cruciate liga-
ment reconstruction are equal in a porcine model.
Arthroscopy 2013;28:672–680.
Yoshida R, Murray MM. Peripheral blood mononu-
clear cells enhance the anabolic effects of platelet-
rich plasma on anterior cruciate ligament fibrob-
lasts. J Orthop Res 2013;31:29–34.
Yoshida R, Cheng M, Murray MM. Increasing platelet
concentration in platelet-rich plasma inhibits ante-
rior cruciate ligament cell function in three-
dimensional culture. J Orthop Res 2014;32:291–295.
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