Science - USA (2022-05-27)
926 27 MAY 2022 • VOL 376 ISSUE 6596 science.org SCIENCE PHOTO: NASA By Catherine Heymans O ne hundred years ago in May 1922, th ...
928 27 MAY 2022 • VOL 376 ISSUE 6596 science.org SCIENCE PHOTO: BRUNO KELLY/AGÊNCIA AMAZÔNIA REAL Edited by Jennifer Sills War s ...
SCIENCE science.org 27 MAY 2022 • VOL 376 ISSUE 6596 929 T. Pimentel, “Estudo da UFMG contradiz Bolsonaro sobre exploração de p ...
DEVELOPMENT Demethylation controls development FTO was the first discov- ered RNA demethylase that reverses messenger RNA N^6 -m ...
TRANSCRIPTION Lampbrush loops in the nucleus RNA polymerase II in the nucleus transcribes the instruc- tion in a gene into a mes ...
sciencemag.org SCIENCE CANCER GENOMICS Grouping prostrate cancers Therapeutic interventions are needed for prostate tumors that ...
SCIENCE sciencemag.org responses to environmental antigens. Atopic individuals have increased susceptibility to bacterial and vi ...
TRANSCRIPTION Lampbrush loops in the nucleus RNA polymerase II in the nucleus transcribes the instruc- tion in a gene into a mes ...
strength or duration decides the developing T cell’s fate has been a matter of much debate. Shinzawa et al. generated FlipFlop m ...
RESEARCH ARTICLE SUMMARY ◥ CANCER GENOMICS Chromatin profiles classify castration-resistant prostate cancers suggesting therapeu ...
RESEARCH ARTICLE ◥ CANCER GENOMICS Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targ ...
Tanget al., Science 376 , eabe1505 (2022) 27 May 2022 2of13 Feature Promoter (<=1kb) 5' UTR 1st Exon Other Exon 1st Intron Ot ...
test). The signature peaks for each subtype, defined as those with log 2 (fold change) > 2 andP < 0.01, were enriched at e ...
factors, hormones, cytokines, inflammation, and stresses. It controls the expression of many downstream genes related to cell di ...
adjustedP < 0.05) ( 12 ). Finally, the relative expression levels of predicted key TFs in each of the four groups were confir ...
(tables S5 and S9). A template was constructed for each subtype by combining the top signa- ture genes. To assign the CRPC patie ...
and 100 patients sequenced at Weill Cornell Medicine (WCM) (Fig. 4B). The majority of the patients (206 of 266 SU2C, 82 of 100 W ...
and 22Rv1 (Fig. 6C and fig. S19C;P < 0.0001, two-tailed unpairedt test). AP-1 and YAP/TAZ are important for subtype-specific ...
Tanget al., Science 376 , eabe1505 (2022) 27 May 2022 9of13 WANG_YAP_TAZ_TARGETSNES = -1.79 FDR = 0.001 Enrichment score (ES) D ...
well as TEAD, which cooperates with FOSL1 in our proposed model, similar to observations in other cancers ( 35 ). Using ChIP-seq ...
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