Science - USA (2020-01-03)
REVIEW ◥ NEUROSCIENCE Memory engrams: Recalling the past and imagining the future Sheena A. Josselyn1,2,3,4,5and Susumu Tonegawa ...
memory to emerge ( 20 ). Memories are re- trieved when appropriate retrieval cues success- fully reactivate an engram in a proce ...
serves as a sufficient retrieval cue to“reawaken” a dormant engram to induce memory expres- sion, similar to Semon’s original de ...
of these ensembles while mice were in the homecage was sufficient to induce a false mem- ory; mice froze in the tagged (but nons ...
Second, compared to nonengram CA3 cells, downstream CA3 engram cells were more functionally connected with upstream DG en- gram ...
becausethemajorityofCA1neuronsaresilent ( 136 ). Those neurons with relatively higher ex- citability immediately before placemen ...
couldnotberetrievedbynaturalmeans.Silent DG engram cells showed weaker physiological (increased synaptic strength) and structura ...
The finding that optogenetically stimulating a silent engram in an otherwise amnestic mouse, even 1 week after training, induces ...
between different engram ensemble components is important in systems consolidation. Memories may also become less precise and mo ...
However, the results of these intervention studies provide direction as to which processes we should focus our efforts to unders ...
Although recent engram studies have of- fered important insights into memory, several key questions remain. First, although the ...
S. Ramirezet al., Creating a false memory in the hippocampus.Science 341 , 387–391 (2013). doi:10.1126/ science.1239073; pmid: ...
H. S. Kudrimoti, C. A. Barnes, B. L. McNaughton, Reactivation of hippocampal cell assemblies: Effects of behavioral state, expe ...
onto the lateral amygdala.Eur. J. Neurosci. 30 , 2089– 2099 (2009). doi:10.1111/j.1460-9568.2009.07004.xpmid: 20128847 C.-H. Li ...
RESEARCH ARTICLE ◥ NANOPARTICLES Oriented attachment induces fivefold twins by forming and decomposing high-energy grain boundar ...
Songet al.,Science 367 ,40–45 (2020) 3 January 2020 2of6 Fig. 2. 5-FT formation mechanism 1 through OA, atomic surface diffusion ...
( 26 ), presenting a hexagonal two-dimensional (2D) projection composed of four {111} and two {200} planes (Fig. 1A). During thi ...
bIIIranging from 71° to 74° (~72° on average) (Fig. 3F). By contrast, region II was barely affected, andbIIremained at ~70° (Fig ...
S 34 andS 35 , forming 5-FT (Fig. 6, C and D) by means of mechanism 1. At a ~149° concave surface induced through OA (Fig. 6, E ...
L. Lu, X. Chen, X. Huang, K. Lu,Science 323 ,607– 610 (2009). M. R. Langille, J. Zhang, M. L. Personick, S. Li, C. A. Mirkin, S ...
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