Nature - USA (2020-02-13)
compounds for inhibition; C3361 was synthesized by BOC Sciences and the MVV009085-homologue was supplied by Mcule. Transport was ...
Article PCki=cTP−0os(∨CTki−0) in which Ti−0 is the vector between the coordinates of i structure and the chosen reference 0 (4YB ...
Extended Data Fig. 1 | See next page for caption. ...
Article Extended Data Fig. 1 | Pf HT1 is distantly related to both the human GLUT transporters and the bacterial homologue XylE. ...
Extended Data Fig. 2 | Pf HT1 has evolved to be an eff icient polyspecif ic sugar transporter. a, Size-exclusion chromatogram of ...
Article Extended Data Fig. 3 | Pf HT1 has evolved to be an eff icient polyspecif ic sugar transporter. a, Zero trans kinetics of ...
Extended Data Fig. 4 | See next page for caption. ...
Article Extended Data Fig. 4 | Overall structural features of the Pf HT1 structure. a, Pf HT1 crystallized as a dimer with four ...
Extended Data Fig. 5 | Sugars assessed for inhibition of Pf HT1. a, Chemical structures of the investigated sugars used in compe ...
Article Extended Data Fig. 6 | See next page for caption. ...
Extended Data Fig. 6 | Assessed quality of purif ied Pf HT1–GFP fusions and analysis of the sugar-binding pocket of Pf HT1. a, F ...
Article N N O O O O HO OH N N O O O O MMV009085 MMV009085derivative O O HO CH 2 OH HO OH HN OH H O O OH O Cytochalasin B C3361 E ...
Extended Data Fig. 8 | See next page for caption. ...
Article Extended Data Fig. 8 | The extracellular substrate-gating helix TM7b. a, Cartoon representation of TM7b of human GLUT3 i ...
Extended Data Fig. 9 | See next page for caption. ...
Article Extended Data Fig. 9 | PCA analysis of sugar-porter structure and alternating-access mechanism. a, Aligned core of near- ...
Extended Data Table 1 | Zero trans proteoliposome (lacking internal sugar) in vitro kinetics of d-glucose and d-fructose by PfHT ...
Article Extended Data Table 2 | Data collection and refinement statistics (molecular replacement) Data were obtained by scaling ...
1 nature research | reporting summary April 2018 Corresponding author(s): David Drew Reporting Summary Nature Research wishes to ...
2 nature research | reporting summary April 2018 Data Policy information about availability of data All manuscripts must include ...
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