Nature - USA (2020-02-13)
266 | Nature | Vol 578 | 13 February 2020 Article Tobacco smoking and somatic mutations in human bronchial epithelium Kenichi Yo ...
Nature | Vol 578 | 13 February 2020 | 267 obtained from subjects who underwent a bronchoscopy for clinical indications. The neve ...
268 | Nature | Vol 578 | 13 February 2020 Article SBS-1 is enriched during early lung development and continues stead- ily throu ...
Nature | Vol 578 | 13 February 2020 | 269 T:A pairing. This is consistent with in vitro data that show that purines are more rea ...
270 | Nature | Vol 578 | 13 February 2020 Article and Sig-A. Phylogenetically, cells with a near-normal mutational burden showed ...
Nature | Vol 578 | 13 February 2020 | 271 (neutral) variants, correcting for local variation in mutation rates^12. With hypothes ...
272 | Nature | Vol 578 | 13 February 2020 Article burden, and this finding probably therefore applies to smokers more generally. ...
Methods Data reporting No statistical methods were used to predetermine sample size. The experiments were not randomized and the ...
Article probability of 0.5 (0.95 for sex chromosomes in males). The alternative hypothesis was that these variants were drawn fr ...
Construction of phylogenetic trees Phylogenetic trees were built with maximum parsimony using sub- stitutions for each patient. ...
Article smoking status, as well as the fixed effects of age and smoking status, were fitted into the model. Reporting summary Fu ...
Extended Data Fig. 1 | See next page for caption. ...
Article Extended Data Fig. 1 | Flow-sorting strategy of single basal bronchial epithelial cells. a, Sorting of EpCAM+ epithelial ...
Extended Data Fig. 2 | Quality assurance of mutation calls. a, Stacked bar chart showing the proportion of reads attributed to t ...
Article Extended Data Fig. 3 | See next page for caption. ...
Extended Data Fig. 3 | Colonies with a near-normal mutational burden. a, Density distribution of mutational burden in cells from ...
Article Extended Data Fig. 4 | Indels, copy-number changes and structural variants in normal bronchial epithelial cells. a, Rela ...
Extended Data Fig. 5 | See next page for caption. ...
Article Extended Data Fig. 5 | Comparison of mutational signatures that were extracted using two algorithms. a, Trinucleotide co ...
Extended Data Fig. 6 | Phylogenetic trees of 13 subjects. Phylogenetic trees showing clonal relationships among normal bronchial ...
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