The Scientist - USA (2020-04)

04.2020 | THE SCIENTIST 23 LUCY READING-IKKANDA ...

It’s a familiar refrain. The vast major- ity of cancer deaths in the US come about not because of a lack of treatment, but becau ...

cellular pathway, “the pressure on the cells to come up with a resistance mech- anism is quite strong,” Rossanese says. Any muta ...

tance in a murine model of an aggressive type of acute lymphoblastic leukemia (ALL) called Philadelphia chromo- some–positive AL ...

04.2020 | THE SCIENTIST 27 Hunger games About 15 years ago, while perusing internet news, Robert Gatenby came across an article ...

LUCY READING-IKKANDA More recently, Gatenby’s group has used the method in patients with meta- static castration-resistant prost ...

04.2020 | THE SCIENTIST 29 says, “physicians as a group did not like it. [At conferences] the usual comment was, ‘This is bullsh ...

CANCER INTRUSION: Bacteria (pink) cozy up to dividing colorectal cancer cells (blue) in this false-color scanning electron micro ...

Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to the fusion of ...

32 THE SCIENTIST | the-scientist.com release the drug over time. In that sense, basic forms of nanorobots are already in clinica ...

04.2020 | THE SCIENTIST 33 WIKIMEDIA COMMONS, NIAID itive and negative feedback motifs to modulate dynamic cel- lular functions, ...

BUILDING BACTERIA TO FIGHT CANCER Synthetic biologists are applying new strategies in genetic engineering to encode traits and s ...

MAGNETICALLY ASSISTED NAVIGATION Sylvain Martel of Polytechnique Montréal and colleagues attached drug-containing nanoliposomes ...

there will be a big push to determine the optimal bacterial strain, payload, circuitry, and appropriate clinical settings in whi ...

pressure waves as external energy to push them deep into tumor tissues. This approach achieved especially promising results in g ...

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40 THE SCIENTIST | the-scientist.com M athilde was diagnosed with breast cancer at the age of 44. Doctors treated her with surge ...

04.2020 | THE SCIENTIST 41 sex hormones, insulin, and inflamma- tory molecules.^4 However, this effect is only seen if exercise ...

EXERCISE’S ANTICANCER MECHANISMS  1 Exercising muscles release multiple compounds known as myokines. Several of these, includin ...