Science - USA (2020-07-10)
SCIENCE sciencemag.org 10 JULY 2020 • VOL 369 ISSUE 6500 153 PHOTO: (CLOCKWISE FROM LEFT) O. J. HARRISON ET AL . ( 9 ); COURTESY ...
154 10 JULY 2020 • VOL 369 ISSUE 6500 STRUCTURAL BIOLOGY Engineering a toxin Developing drugs that target a specific subtype in ...
10 JULY 2020 • VOL 369 ISSUE 6500 155 EPIDEMIOLOGY Early warning signs Modeling an emerging infectious disease is an inexact sci ...
156 10 JULY 2020 • VOL 369 ISSUE 6500 sciencemag.org SCIENCE RESEARCH | IN OTHER JOURNALS trained on data collected for mumps ou ...
REVIEW SUMMARY ◥ LYMPHATIC BIOLOGY Biological functions of lymphatic vessels Tatiana V. Petrova*and Gou Youngo Koh* BACKGROUND:B ...
RESEARCH ARTICLE SUMMARY ◥ DEVELOPMENTAL BIOLOGY Contact area–dependentcell communication and the morphological invariance of as ...
RESEARCH ARTICLE SUMMARY ◥ ORGANOIDS Human CNS barrier-forming organoids with cerebrospinalfluid production Laura Pellegrini, Cl ...
RESEARCH ARTICLE SUMMARY ◥ CORONAVIRUS Inferring change points in the spread of COVID-19 revealsthe effectiveness of interventio ...
RESEARCH ARTICLES ◥ STRUCTURAL BIOLOGY Structure and selectivity engineering of the M 1 muscarinic receptor toxin complex Shoji ...
subtype-specific residues engaged in MT7 bind- ingalsoformpartofthebindingpocketof M 1 AChR-selective small-molecule allosteric ...
SCIENCEsciencemag.org 10 JULY 2020•VOL 369 ISSUE 6500 163 Fig. 2. Conformational changes in M 1 AChR stabilized by MT7 binding.( ...
M 1 AChR and has conformational selectivity toward the inactive state (Fig. 3, A and B). Moreover, it confers a slow dissociatio ...
tiotropium has two rings (Fig. 5B). The pref- erential allosteric effects of Tx24 for these smaller antagonists are likely due t ...
size of Tx24, it is likely that it interacts with W4227.35and provides M4066.54with a differ- ent microenvironment in the apo st ...
experiments. We thank staff at Advanced Photon Source GM/CA beamlinesfor technical assistance and support for data collection. W ...
To assess the potential of plasma from exer- cisedmice to rescue age-related impairments in hippocampal-dependent learning and m ...
factorsacrossagescanconferthebenefitsof exercise on the aged hippocampus. Gpld1 ameliorates age-related regenerative and cogniti ...
expression of BDNF (Fig. 3G) in the hippo- campus of aged mice overexpressing Gpld1 in liver. To assess the effect of Gpld1 over ...
Coagulation and complement signaling cascadesare altered in response to Gpld1 We sought to delineate central versus peripheral m ...
172 10 JULY 2020•VOL 369 ISSUE 6500 sciencemag.org SCIENCE 0 10000 20000 30000 40000 50000 Relative Luminescence CtrlGpld1H133NH ...
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