Science - USA (2020-08-21)
interferon-b(IFN-b) secretion, a known effect of STING agonism. Using human monocytic THP-1 cells that express the naturally occ ...
Panet al.,Science 369 , eaba6098 (2020) 21 August 2020 3of10 Fig. 3. MSA-2 is an orally bioavailable STING agonist with in vivo ...
in a STING dimer. In Model 2, binding of a monomeric MSA-2 molecule to one STING sub- unit alters the MSA-2 affinity of the unoc ...
findings, Model 1 was ruled out. Simulations showed that both Model 2 and Model 3 could, under certain conditions, display a con ...
various substitutions—represents a general pharmacophore for potent STING agonism. We selected compound 3 as the most rea- sonab ...
is primarily by passive diffusion of uncharged MSA-2, we hypothesized that acidification of the extracellular environment, such ...
D, and fig. S10). Combination regimens with lower MSA-2 levels achievedthesameefficacy end point with improved tolerability (bod ...
in an acidified tumor microenvironment (ver- sus normal tissue), owing to increased cellular entry and retention combined with i ...
C. Zhanget al., Structural basis of STING binding with and phosphorylation by TBK1.Nature 567 , 394–398 (2019). doi:10.1038/s41 ...
RESEARCH ARTICLE ◥ CANCER IMMUNOLOGY Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacterio ...
screened the differential capacity ofE. hirae strains to elicit memory T cell responses after priming of the host, measured as t ...
a specific increase in splenic CD8+T cells that recognized the TMP1 peptide (but not the OVA peptide SIINFEKL) at day 7 after tr ...
induced dysbiosis. Introducing a knock-in mutation in position 3 of PSMB4 into TC1 lung cancer cells again compromised the anti- ...
functional data, half of the CD8+T cells labeled with PSMB4-H-2Kbtetramers shared clono- types with the much wider TCR repertoir ...
means of transmission electron microscopy revealed numerous phages with the typical Siphoviridaemorphology in the medium, wherea ...
C. P. Bradleyet al.,Cell Host Microbe 22 , 697–704.e4 (2017). S. Viaudet al.,Science 342 , 971–976 (2013). M. G. Weinbauer,FEMS ...
CANCER IMMUNOLOGY BTN3A1 governs antitumor responses by coordinating abandgdT cells Kyle K. Payne^1 , Jessica A. Mine^1 , Subir ...
prognostically relevant BTN3A1 effectively sup- pressabT cell responses. Human anti-CD277 prevent BTN3A1-mediated inhibition of ...
Payneet al.,Science 369 , 942–949 (2020) 21 August 2020 3of8 Fig. 2. BTN3A1-specific antibodies relieveabT cell inhibition and a ...
Payneet al.,Science 369 , 942–949 (2020) 21 August 2020 4of8 Fig. 3. BTN3A1 interacts with the CD45 phospha- tase, blunting prox ...
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