Science - USA (2020-08-21)

(Fig. 2K and fig. S3C), suggesting that the switch between theab-immunosuppressive and Vg9Vd2-immunostimulatory activities of BT ...

and the phosphatase PTPN6 (SHP-1) (Fig. 3B and file S3). CD45 similarly consistently coimmunoprecipitated with BTN3A1 from nonac ...

and fig. S5C), and CD45−Jurkat cells with ectopic expression of CD45RA and CD45RO (fig. S5, D and E) all showed significantly re ...

by binding to N-mannosylated residues in human CD45, preventing its segregation from the immune synapse and promoting its dimer- ...

LIQUID CRYSTALS Shaping colloidal bananas to reveal biaxial, splay-bend nematic, and smectic phases Carla Fernández-Rico^1 , Mas ...

In this work, we develop a method to produce, in bulk, fluorescent curved colloidal rods—colloidal bananas—with tunable dimen- s ...

shearing an emulsion of SU-8 droplets in a viscous medium ( 29 , 30 ). During the second step, the resulting rods are partially ...

the sample container to which the bananas align because this facilitates a quantitative 2D structural analysis at the particle l ...

which is reminiscent of the elusive biaxial splay- bend nematic phase. Splay-bend nematic phase in colloidal bananas To distingu ...

(f= 0.60 to 0.79) for the bananas with the lowest curvature (k=0.07mm−^1 ). First, we observe that the number density profiles, ...

CORONAVIRUS Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model Thomas F. ...

with COVID-19, and disease severity ranged from mild to severe, including intubation in one case, although all donors recovered. ...

high-throughput screening were sequence- confirmed and advanced for large-scale expres- sion for additional characterization. Th ...

other antibodies grouped in the S-A epitope bin that compete with CC12.19 either showed no binding to RBD or RBD-SD constructs ( ...

evidenced, for example, in the emergence of the D614G variant ( 9 ). We investigated the activity of five nAbs against six viral ...

Passive transfer of neutralizing antibodies and SARS-CoV-2 challenge in Syrian hamsters To investigate the relationship between ...

against disease from SARS-CoV-2 infection, we also measured the antibody serum concen- trations just before intranasal virus cha ...

plasma and PBMC samples. F.Z., A.B., L.Y., M.P., and G.S. performed ELISA and cell binding assays. F.Z., D.H., N.B., L.Y., M.P., ...

GLOBAL CLIMATE CHANGE Synchronous timing of abrupt climate changes during the last glacial period Ellen C. Corrick1,2*, Russell ...

We standardized all speleothem time series to avoid methodological bias in age calcula- tions and depth-age model construction t ...