Science - USA (2020-08-21)

Nehrbass-Ahleset al.,Science 369 , 1000–1005 (2020) 21 August 2020 3of6 Fig. 2. Comparison of high-resolution CO 2 and improved ...

50 parts per billion (ppb) (Figs. 1C and 3C) and growth rates exceeding 20 ppb per cen- tury, as recorded in the EDC ice core (F ...

3B and table S1) at 415 ka BP, occurring ~10 ka into interglacial temperature conditions at Dome C, but still at a time of consi ...

P. U. Clarket al.,Nat. Clim. Chang. 6 , 360–369 (2016). C. Nehrbass-Ahleset al., High-resolution atmospheric CO 2 and CH 4 reco ...

MICROBIOLOGY Architecture and function of human uromodulin filaments in urinary tract infections Gregor L. Weiss^1 , Jessica J. ...

high-mannose N-glycan at Asn^275 of the UMOD arm is the only accessible FimHL-recognition site. We next analyzed binding of UMOD ...

(TIRF) microscopy showed that cell aggregates colocalized with UMOD (Fig. 3D). UMOD- dependent cell aggregation also occurred wi ...

of uroplakin 1a on the urinary epithelium ( 4 , 14 , 27 ). The intrinsic flexibility of UMOD filaments allows their adaptation t ...

The seven different complex-type N-glycans on UMOD (Fig. 1A) may therefore competitively inhibit adhesion of other pathogens to ...

EMD-11128 and EMD-11129 (native UMOD), EMD-11130 and EMD11131 (eUMOD), EMD-1133 and EMD-11134 (UMOD incubated with FimHL), and E ...

CORONAVIRUS Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail Johanna Hansen^1 , Alina Baum ...

of overlaid sequences (fig. S2) showed strong overlap in the repertoire of isolated kappa chains between VI mouse and human-deri ...

binding, cross-linking, and steric hindrance might all augment neutralization. Althoughtheroleofantibodyeffectorfunc- tion in pr ...

the Fab region of REGN10933 binds the RBD from the top direction,where REGN10933 will have collisions with ACE2. To avoid compet ...

L. E. Macdonaldet al.,Proc. Natl. Acad. Sci. U.S.A. 111 , 5147 – 5152 (2014). K. E. Pascalet al.,J. Infect. Dis. 218 , S612–S62 ...

CORONAVIRUS Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies Alina ...

Baumet al.,Science 369 , 1014–1018 (2020) 21 August 2020 2of4 Table 1. Anti-SARS-CoV2 spike mAbs demonstrate broad neutralizatio ...

VSV-SARS-CoV-2 spike pseudoparticles ex- pressing the individual identified spike mu- tations. These pseudoparticles were used i ...

however, this strategy may not suffice. Although some informed analysis can be made regard- ing epitope conservation based on se ...

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