Science - USA (2020-10-02)
SCIENCE sciencemag.org ILLUSTRATION: MIXMAGIC/ISTOCK.COM in their own country or in another “third country” in order to complete ...
INSIGHTS | POLICY FORUM sciencemag.org SCIENCE for research purposes. The GDPR also allows for an exception to the notice requir ...
SCIENCE sciencemag.org 2 OCTOBER 2020 • VOL 370 ISSUE 6512 43 PHOTO: SHAUN CURRY/AFP/GETTY IMAGES O n 26 February 1998, the Roya ...
44 2 OCTOBER 2020 • VOL 370 ISSUE 6512 sciencemag.org SCIENCE PHOTO: ISTOCK.COM/POBA H ow do you engage with an institu- tion th ...
SCIENCE sciencemag.org 2 OCTOBER 2020 • VOL 370 ISSUE 6512 45 By Christopher A. Zimmerman W e experience thirst every day, but w ...
46 2 OCTOBER 2020 • VOL 370 ISSUE 6512 sciencemag.org SCIENCE PHOTOS: (TOP TO BOTTOM) SAMEER A. KHAN; MELISSA PENLEY CORMIER/RES ...
Whatever projects you’re working on, from exploring mechanisms of disease to creating personalized therapies, you can count on o ...
PHOTO: CREDIT GOES HERE AS SHOWN; CREDIT GOES HERE AS SHOWN NEURODEGENERATION SPECIAL SECTION N eurodegeneration is an all-too-c ...
ILLUSTRATION: SIMON PRADES Neurodegeneration can stop people from being able to perform the most basic tasks in life. However, p ...
REVIEW Glymphatic failure as a final common pathway todementia Maiken Nedergaard1,2and Steven A. Goldman1,2 Sleep is evolutionar ...
subarachnoid spaces surrounding the brain, fromwhich CSF is rapidly driven into deep regions of the brain by the cardiac rhythm– ...
in the deep cervical lymph nodes within min- utesafter CSF delivery ( 42 – 45 ). Nonetheless, proteins and tracers can circulate ...
or in combination, can lead to self-aggregation with the formation of stableb-sheet–rich strands. Reduced glymphatic clearance m ...
Sleep, aging, neurodegeneration, and the glymphatic system The most substantial risk factor for developing protein aggregation, ...
unappreciated role in the clearance of neuro- toxic waste from the brain. In particular, we have found that the brain’s fluid tr ...
C. Soto,Nat. Rev. Neurosci. 4 , 49–60 (2003). C. Soto, S. Pritzkow,Nat. Neurosci. 21 , 1332–1340 (2018). K. A. Burke, E. A. Yat ...
where the precursor liquid phase can be either the dilute solution of macromolecules or the dense phase formed via LLPS. Many pr ...
condensates containing hundreds of distinct biomolecules that function as discrete mem- braneless organelles. Indeed, a cell may ...
homotypic phase transition leading to fibril for- mation; and second, a mode of toxicity in which pathological phase transitions ...
percolation threshold and material properties of specific condensates. Thus, one promising approach to restoring material proper ...
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