Science - USA (2020-09-25)

GSDMD was essential for cell infiltration to the CNS during EAE. Mice receiving DMF demonstrated reduced infiltration of myeloid ...

responds to proximity. To be generally useful, the actuation must be modular and inde- pendent of target antigen identity. We be ...

Previous LOCKR switches functioned in the yeast cytoplasm ( 3 ) but were aggregation- prone once purified, likely because of dom ...

lymphoma 2; Bim, Bcl2-interacting mediator of cell death) ( 6 ). Bim was encoded into the latch as a sequestered peptide, and Bc ...

that tuning the cage–latch interface enhanced colocalization-dependent signal without com- promising specificity (Fig. 2B and fi ...

the lowest off-target activation (fig. S6B), and I287A exhibited the highest specificity (on- target signal divided by max off-t ...

combinations of AND and either OR or NOT logic. CAR T cells cocultured with AND/OR Co-LOCKRs (CL_CHKEKEp, CL_CEKHKEp, and CL_CEp ...

PARASITE GENETICS A single-cell RNA-seq atlas ofSchistosoma mansoni identifies a key regulator of blood feeding George Wendt^1 , ...

male stimulus. Thus, male parasites may reg- ulate this developmental checkpoint by pro- moting survival of differentiating GSCs ...

unexpected numbers of male cells in clusters of female sexual tissues, which we attribute to neoblasts expressing low levels of ...

(fig. S15D). Examination of the expression of eledand the gut markerctsbrevealed that locations whereeled+neoblasts were abun- d ...

hnf4RNAi (tables S1 and S4). Together, these data suggest thathnf4is at least indirectly required for the digestion of hemoglobi ...

Data and materials availability:A searchable database of scRNA- seq data can be accessed at http://www.collinslab.org/schistocyt ...

in vitro either by automated worm movement tracking or on the basis of parasite attach- ment.Morethanhalfofthecompoundstested (8 ...

Aside from RNAi ofstk25andtao, this banana- shaped phenotype of worms was distinctive, as it was only observed after RNAi of a C ...

By examining the tissue-specific expression of differentially regulated genes on an adult schistosome single-cell expression atl ...

provides a new lens to prioritize genes of in- terest in other medically and agriculturally important parasitic flatworms. Colle ...

of the human Y chromosome (Fig. 1B) ( 14 ). This yielded sequence coverage of 1.4× for Denisova 4, 3.5× for Denisova 8, 0.8× for ...

bias in the data (fig. S7), we observed no con- sistent differences between capture data and shotgun sequences or between indivi ...

1253 shares with both Neanderthals and mod- ern humans being converted to the ancestral state, increasing the apparent TMRCA. Wh ...