BNF for Children (BNFC) 2018-2019

Penicillinase-resistant penicillins Most staphylococci are now resistant to benzylpenicillin sodium because they produce penicil ...

then specialist advice should be sought on hypersensitivity testing or using a beta-lactam antibiotic with a different structure ...

Dose adjustments▶In neonatesReduce dose if estimated glomerularfiltration rate less than 60 mL/minute/ 1. 73 m 2 . ▶In childrenU ...

lMEDICINAL FORMS There can be variation in the licensing of different medicines containing the same drug. Forms available from s ...

▶Child: 20 – 30 mg/kg every 8 hours (max. per dose 500 mg), increased if necessary to 40 – 60 mg/kg every 8 hours (max. per dose ...

Medicines for Children leaflet: Amoxicillin for bacterial infectionswww.medicinesforchildren.org.uk/amoxicillin- bacterial-infec ...

erythematous rashes).glandular fever (erythematous rashes common) SPECIFIC CAUTIONS ▶With intravenous useAccumulation of electro ...

Powder for solution for injection ELECTROLYTES:May contain Sodium ▶Co-fluampicil (Non-proprietary) Ampicillin (as Ampicillin sod ...

lPREGNANCYNot known to be harmful. lBREAST FEEDINGTrace amount in milk, but appropriate to use. lHEPATIC IMPAIRMENT MonitoringMo ...

lINTERACTIONS→Appendix 1 : penicillins lSIDE-EFFECTS ▶Common or very commonVulvovaginal fungal infection ▶UncommonDizziness.fati ...

.flucloxacillin should not be used in patients with a history of hepatic dysfunction associated with flucloxacillin .flucloxacil ...

PROMIXIN®INJECTION Gram-negative infections resistant to other antibacterials, including those caused byPseudomonas aeruginosa,A ...

▶Promixin(Profile Pharma Ltd) Colistimethate sodium 1000000 unitPromixin 1 million unit powder for solution for injection vials| ...

Complicated urinary-tract infections ▶BY MOUTH ▶Neonate: 10 mg/kg twice daily. ▶Child: 10 mg/kg twice daily, dose to be doubled ...

ANTIBACTERIALS›SULFONAMIDES Co-trimoxazole lDRUG ACTIONSulfamethoxazole and trimethoprim are used in combination (as co-trimoxaz ...

lMEDICINAL FORMS There can be variation in the licensing of different medicines containing the same drug. Solution for infusion ...

lupus-erythematosus-like syndrome. Minocycline sometimes causes irreversible pigmentation. Tetracyclines have a role in the mana ...

Periodontitis (as an adjunct to gingival scaling and root planing) ▶BY MOUTH USING IMMEDIATE-RELEASE MEDICINES ▶Child 12–17 year ...

lLESS SUITABLE FOR PRESCRIBINGLess suitable for prescribing (compared with other tetracyclines, minocycline is associated with a ...

▶BY INTRAVENOUS INJECTION ▶Neonate up to 14 days: 12. 5 mg/kg twice daily, doses should be checked carefully as overdosage can b ...