▶Crizotinibis predicted to increase the exposure tocabazitaxel.
oTheoretical→Also seeTABLE 15p. 850
▶Efavirenzis predicted to decrease the exposure tocabazitaxel.
Avoid.rStudy
▶Eliglustatis predicted to increase the exposure topaclitaxel.
Adjust dose.oStudy
▶Enzalutamideis predicted to decrease the exposure to
docetaxel.rTheoretical
▶Enzalutamideis predicted to decrease the exposure totaxanes
(cabazitaxel, paclitaxel). Avoid.rStudy
▶Fibrates(gemfibrozil)are predicted to increase the
concentration ofpaclitaxel.rAnecdotal
▶HIV-protease inhibitorsare predicted to increase the exposure
tocabazitaxel. Avoid.rStudy
▶HIV-protease inhibitorsare predicted to moderately increase
the exposure todocetaxel. Avoid or adjust dose.rStudy
▶HIV-protease inhibitorsare predicted to increase the exposure
topaclitaxel.rTheoretical
▶Idelalisibis predicted to increase the exposure tocabazitaxel.
Avoid.rStudy→Also seeTABLE 15p. 850
▶Idelalisibis predicted to moderately increase the exposure to
docetaxel. Avoid or adjust dose.rStudy→Also seeTABLE 15
p. 850
▶Idelalisibis predicted to increase the exposure topaclitaxel.
rTheoretical→Also seeTABLE 15p. 850
▶Imatinibis predicted to increase the exposure tocabazitaxel.
oTheoretical→Also seeTABLE 15p. 850
▶Lapatinibslightly increases the exposure topaclitaxel.r
Study
▶Leflunomideis predicted to increase the concentration of
paclitaxel.rAnecdotal→Also seeTABLE 15p. 850
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given withtaxanes
(docetaxel, paclitaxel). Public Health England advises avoid
(refer to Green Book).rTheoretical
▶Macrolides(clarithromycin)are predicted to increase the
exposure tocabazitaxel. Avoid.rStudy
▶Macrolides(clarithromycin)are predicted to moderately
increase the exposure todocetaxel. Avoid or adjust dose.
rStudy
▶Macrolides(clarithromycin)are predicted to increase the
exposure topaclitaxel.rTheoretical
▶Macrolides(erythromycin)are predicted to increase the
exposure tocabazitaxel.oTheoretical
▶Mirabegronis predicted to increase the exposure topaclitaxel.
nTheoretical
▶Mitotaneis predicted to decrease the exposure todocetaxel.
rTheoretical→Also seeTABLE 15p. 850
▶Mitotaneis predicted to decrease the exposure totaxanes
(cabazitaxel, paclitaxel). Avoid.rStudy→Also seeTABLE 15
p. 850
▶Netupitantis predicted to increase the exposure tocabazitaxel.
oTheoretical
▶Nevirapineis predicted to decrease the exposure to
cabazitaxel. Avoid.rStudy
▶Nilotinibis predicted to increase the exposure tocabazitaxel.
oTheoretical→Also seeTABLE 15p. 850
▶Pitolisantis predicted to decrease the exposure todocetaxel.
Avoid.rTheoretical
▶Rifampicinis predicted to decrease the exposure todocetaxel.
rTheoretical
▶Rifampicinis predicted to decrease the exposure totaxanes
(cabazitaxel, paclitaxel). Avoid.rStudy
▶St John’s Wortis predicted to decrease the exposure to
cabazitaxel. Avoid.rStudy
▶Teriflunomideis predicted to increase the concentration of
paclitaxel.rAnecdotal
▶Velpatasviris predicted to increase the exposure topaclitaxel.
rTheoretical
Tazarotene→see retinoids
Tedizolid
▶Tedizolidis predicted to increase the exposure toimatinib.
Avoid.oTheoretical
▶Tedizolidis predicted to increase the exposure tolapatinib.
Avoid.oTheoretical
▶Tedizolidis predicted to increase the exposure to
methotrexate. Avoid.oTheoretical
▶Tedizolidincreases the exposure tostatins(rosuvastatin).
Avoid.oStudy
▶Tedizolidis predicted to increase the exposure tosulfasalazine.
Avoid.oTheoretical
▶Tedizolidis predicted to increase the exposure totopotecan.
Avoid.oTheoretical
Tegafur
▶Tegafurpotentially increases the concentration of
antiepileptics(fosphenytoin, phenytoin). Monitor concentration
and adjust dose.rAnecdotal
▶Tegafurincreases the anticoagulant effect ofcoumarins.
oTheoretical
▶Folatesare predicted to increase the risk of toxicity when
given withtegafur.rTheoretical
▶H 2 receptor antagonists(cimetidine)are predicted to increase
the risk of toxicity when given withtegafur.rTheoretical
▶Live vaccinesare predicted to increase the risk of generalised
infection (possibly life-threatening) when given withtegafur.
Public Health England advises avoid (refer to Green Book).
rTheoretical
▶Methotrexateis predicted to increase the risk of toxicity when
given withtegafur.rTheoretical
Teicoplanin
GENERAL INFORMATIONIf other nephrotoxic or neurotoxic
drugs are given, monitor renal and auditory function on
prolonged administration.
Telavancin→seeTABLE 2p. 847 (nephrotoxicity),TABLE 19p. 851
(ototoxicity),TABLE 9p. 849 (QT-interval prolongation)
Telbivudine
▶Interferons(interferon alfa)are predicted to increase the risk of
peripheral neuropathy when given withtelbivudine. Avoid.
rTheoretical
▶Interferons(peginterferon alfa)increase the risk of peripheral
neuropathy when given withtelbivudine. Avoid.rStudy
Telmisartan→see angiotensin-II receptor antagonists
Telotristat ethyl
▶Telotristat ethyldecreases the exposure tomidazolam.
oStudy
▶Octreotide(short-acting) decreases the exposure totelotristat
ethyl.Telotristat ethylshould be taken at least 30 minutes
beforeoctreotide,p. 467.oStudy
Temazepam→seeTABLE 11p. 849 (CNS depressant effects)
Temocillin→see penicillins
Temozolomide→see alkylating agents
Temsirolimus→seeTABLE 15p. 850 (myelosuppression)
▶Antiarrhythmics(dronedarone)are predicted to increase the
concentration oftemsirolimus.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the
concentration oftemsirolimus. Avoid.rStudy
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the concentration oftemsirolimus.
oTheoretical
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to increase the concentration oftemsirolimus.
Avoid.rTheoretical
▶Aprepitantis predicted to increase the concentration of
temsirolimus.oTheoretical
▶Bosentanis predicted to decrease the concentration of
temsirolimus. Avoid.rTheoretical
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the concentration oftemsirolimus.o
Theoretical
▶Cobicistatis predicted to increase the concentration of
temsirolimus. Avoid.rTheoretical
▶Crizotinibis predicted to increase the concentration of
temsirolimus.oTheoretical→Also seeTABLE 15p. 850
▶Efavirenzis predicted to decrease the concentration of
temsirolimus. Avoid.rTheoretical
▶Enzalutamideis predicted to decrease the concentration of
temsirolimus. Avoid.rStudy
▶Grapefruit juiceis predicted to increase the concentration of
temsirolimus. Use with caution or avoid.oTheoreticalBNFC 2018 – 2019 Taxanes—Temsirolimus 999
Interactions|Appendix 1A1