recommended range used in severe cases; doses of
50 mg/kg or more should be given by infusion
▶Child 12–17 years: 2 – 4 g once daily, doses at the higher
end of the recommended range used in severe cases
▶BY DEEP INTRAMUSCULAR INJECTION
▶Child 1 month–11 years (body-weight up to
50 kg): 80 – 100 mg/kg daily, 100 mg/kg daily dose
should be used for bacterial endocarditis; maximum 4 g
per day
▶Child 9–11 years (body-weight 50 kg and above): 2 – 4 g
daily, doses at the higher end of the recommended
range used in severe cases
▶Child 12–17 years: 2 – 4 g daily, doses at the higher end of
the recommended range used in severe cases
Surgical prophylaxis
▶BY INTRAVENOUS INFUSION
▶Neonate up to 15 days: 20 – 50 mg/kg for 1 dose, dose to be
administered 30 – 90 minutes before procedure.
▶Neonate 15 days to 28 days: 50 – 80 mg/kg for 1 dose, dose
to be administered 30 – 90 minutes before procedure.
▶Child 1 month–11 years (body-weight up to
50 kg): 50 – 80 mg/kg (max. per dose 2 g) for 1 dose,
dose to be administered 30 – 90 minutes before
procedure
▶Child 9–11 years (body-weight 50 kg and above): 2 gfor
1 dose, dose to be administered 30 – 90 minutes before
procedure
▶Child 12–17 years: 2 gfor 1 dose, dose to be administered
30 – 90 minutes before procedure
▶BY INTRAVENOUS INJECTION
▶Child 9–11 years (body-weight 50 kg and above): 2 gfor
1 dose, dose to be administered 30 – 90 minutes before
procedure
▶Child 12–17 years: 2 gfor 1 dose, dose to be administered
30 – 90 minutes before procedure
▶BY DEEP INTRAMUSCULAR INJECTION
▶Child 1 month–11 years (body-weight up to
50 kg): 50 – 80 mg/kg (max. per dose 2 g) for 1 dose,
dose to be administered 30 – 90 minutes before
procedure
▶Child 9–11 years (body-weight 50 kg and above): 2 gfor
1 dose, dose to be administered 30 – 90 minutes before
procedure
▶Child 12–17 years: 2 gfor 1 dose, dose to be administered
30 – 90 minutes before procedure
Uncomplicated gonorrhoea|Pelvic inflammatory disease
▶BY DEEP INTRAMUSCULAR INJECTION
▶Child 1 month–11 years (body-weight up to 45 kg): 125 mg
for 1 dose
▶Child 9–11 years (body-weight 45 kg and above): 250 mg
for 1 dose
▶Child 12–17 years: 500 mg for 1 dose
Syphilis
▶BY INTRAVENOUS INFUSION
▶Neonate up to 15 days: 50 mg/kg once daily for
10 – 14 days.
▶Neonate 15 days to 28 days: 75 – 100 mg/kg once daily for
10 – 14 days.
▶Child 1 month–11 years (body-weight up to
50 kg): 75 – 100 mg/kg once daily for 10 – 14 days;
maximum 4 g per day
▶Child 9–11 years (body-weight 50 kg and above): 0. 5 – 1 g
once daily for 10 – 14 days, dose increased to 2 g once
daily for neurosyphilis
▶Child 12–17 years: 0. 5 – 1 g once daily for 10 – 14 days,
dose increased to 2 g once daily for neurosyphilis
▶BY INTRAVENOUS INJECTION
▶Child 9–11 years (body-weight 50 kg and above): 0. 5 – 1 g
once daily for 10 – 14 days, dose increased to 2 g once
daily for neurosyphilis
▶Child 12–17 years: 0. 5 – 1 g once daily for 10 – 14 days,
dose increased to 2 g once daily for neurosyphilis
▶BY DEEP INTRAMUSCULAR INJECTION
▶Child 1 month–11 years (body-weight up to
50 kg): 75 – 100 mg/kg daily for 10 – 14 days; maximum
4 g per day
▶Child 9–11 years (body-weight 50 kg and above): 0. 5 – 1 g
once daily for 10 – 14 days, dose increased to 2 g once
daily for neurosyphilis
▶Child 12–17 years: 0. 5 – 1 g once daily for 10 – 14 days,
dose increased to 2 g once daily for neurosyphilis
Disseminated Lyme borreliosis (early [Stage II] and late
[Stage III])
▶BY INTRAVENOUS INFUSION
▶Neonate 15 days to 28 days: 50 – 80 mg/kg once daily for
14 – 21 days, the recommended treatment durations vary
and national or local guidelines should be taken into
consideration.▶Child 1 month–11 years (body-weight up to
50 kg): 50 – 80 mg/kg once daily for 14 – 21 days, the
recommended treatment durations vary and national
or local guidelines should be taken into consideration;
maximum 4 g per day
▶Child 9–11 years (body-weight 50 kg and above): 2 g once
daily for 14 – 21 days, the recommended treatment
durations vary and national or local guidelines should
be taken into consideration
▶Child 12–17 years: 2 g once daily for 14 – 21 days, the
recommended treatment durations vary and national
or local guidelines should be taken into consideration
▶BY INTRAVENOUS INJECTION
▶Child 9–11 years (body-weight 50 kg and above): 2 g once
daily for 14 – 21 days, the recommended treatment
durations vary and national or local guidelines should
be taken into consideration
▶Child 12–17 years: 2 g once daily for 14 – 21 days, the
recommended treatment durations vary and national
or local guidelines should be taken into consideration
▶BY DEEP INTRAMUSCULAR INJECTION
▶Child 1 month–11 years (body-weight up to
50 kg): 50 – 80 mg/kg daily for 14 – 21 days, the
recommended treatment durations vary and national
or local guidelines should be taken into consideration;
maximum 4 g per day
▶Child 9–11 years (body-weight 50 kg and above): 2 g once
daily for 14 – 21 days, the recommended treatment
durations vary and national or local guidelines should
be taken into consideration
▶Child 12–17 years: 2 g once daily for 14 – 21 days, the
recommended treatment durations vary and national
or local guidelines should be taken into consideration
Congenital gonococcal conjunctivitis
▶BY DEEP INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS
INFUSION
▶Neonate: 25 – 50 mg/kg (max. per dose 125 mg) for
1 dose, intravenous infusion to be administered over
60 minutes.Prevention of secondary case of meningococcal meningitis
▶BY INTRAMUSCULAR INJECTION
▶Child 1 month–11 years: 125 mg for 1 dose
▶Child 12–17 years: 250 mg for 1 dose continued→BNFC 2018 – 2019 Bacterial infection 323
Infection5