Calcipotriol with betamethasone
30-May-2017
The properties listed below are those particular to the
combination only. For the properties of the components
please consider, calcipotriol p. 750 , betamethasone p. 735.lINDICATIONS AND DOSE
DOVOBET®GEL
Scalp psoriasis
▶TO THE SKIN
▶Child 12–17 years (specialist use only):Apply 1 – 4 g once
daily usual duration of therapy 4 weeks; if necessary,
treatment may be continued beyond 4 weeks or
repeated, on the advice of a specialist, shampoo off
after leaving on scalp overnight or during day, when
different preparations containing calcipotriol used
together, maximum total calcipiotriol 3. 75 mg in any
one week
Mild to moderate plaque psoriasis
▶TO THE SKIN
▶Child 12–17 years (specialist use only):Apply once daily
usual duration for up to 4 weeks; if necessary
treatment should be continued beyond 4 weeks, or
repeated, only on the advice of a specialist, apply to
maximum 30 % of body surface, when different
preparations containing calcipotriol used together,
max. total calcipotriol 3. 75 mg in any one week;
maximum 75 g per week
DOVOBET®OINTMENT
Stable plaque psoriasis
▶TO THE SKIN
▶Child 12–17 years (specialist use only):Apply once daily
for up to 4 weeks; if necessary, treatment may be
continued beyond 4 weeks or repeated, on the advice of
a specialist, apply to a maximum 30 % of body surface,
when different preparations containing calcipotriol
used together, max. total calcipotriol 3. 75 mg in any
one week; maximum 75 g per weeklUNLICENSED USEDovobet®not licensed for use in
children.
lCONTRA-INDICATIONS
ENSTILAR®Erythrodermic psoriasis.pustular psoriasis
lINTERACTIONS→Appendix 1 : corticosteroids.vitamin D
substanceslMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug.
Ointment
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS:May contain Butylated hydroxytoluene
▶Dovobet(LEO Pharma)
Calcipotriol (as Calcipotriol hydrate) 50 microgram per 1 gram,
Betamethasone (as Betamethasone dipropionate)
500 microgram per 1 gramDovobet ointment| 30 gramP
£ 19. 84 DT = £ 19. 84 | 60 gramP£ 39. 68 | 120 gramP£ 73. 86
Gel
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS:May contain Butylated hydroxytoluene
▶Dovobet(LEO Pharma)
Calcipotriol (as Calcipotriol monohydrate) 50 microgram per
1 gram, Betamethasone (as Betamethasone dipropionate)
500 microgram per 1 gramDovobet gel| 60 gramP£ 37. 21 DT
=£ 37. 21 | 120 gramP£ 69. 11eiiiiF 734Clobetasol propionate 21-Dec-2017
lINDICATIONS AND DOSE
Short-term treatment only of severe resistant
inflammatory skin disorders such as recalcitrant
eczemas unresponsive to less potent corticosteroids|
Psoriasis
▶TO THE SKIN
▶Child 1–17 years:Apply 1 – 2 times a day for up to
4 weeks, to be applied thinly
POTENCY
▶Clobetasol propionate 0. 05 % cream, foam, ointment,
scalp application, and shampoo: very potent.lUNLICENSED USEDermovate®not licensed for use in
children under 1 year.
lPATIENT AND CARER ADVICEPatients or carers should be
given advice on how to administer clobetasol propionate
foam, liquid (scalp application), cream, ointment and
shampoo.
Scalp applicationPatients or carers should be advised to
apply foam directly to scalp lesions (foam begins to
subside immediately on contact with skin).lMEDICINAL FORMS
There can be variation in the licensing of different medicines
containing the same drug. Forms available from special-order
manufacturers include: cream, ointment, paste
Foam
CAUTIONARY AND ADVISORY LABELS15, 28
EXCIPIENTS:May contain Cetostearyl alcohol (including cetyl and
stearyl alcohol), polysorbates, propylene glycol
▶Clarelux(Pierre Fabre Dermo-Cosmetique)
Clobetasol propionate 500 microgram per 1 gramClarelux
500 micrograms/g foam| 100 gramP£ 11. 06 DT = £ 11. 06
Cream
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS:May contain Beeswax, cetostearyl alcohol (including cetyl
and stearyl alcohol), chlorocresol, propylene glycol
▶Clobetasol propionate (Non-proprietary)
Clobetasol propionate 500 microgram per 1 gramClobetasol
0. 05 % cream| 30 gramPsDT = £ 2. 69 | 100 gramPsDT =
£ 7. 90
▶ClobaDerm(Auden McKenzie (Pharma Division) Ltd)
Clobetasol propionate 500 microgram per 1 gramClobaDerm
0. 05 % cream| 30 gramP£ 2. 15 DT = £ 2. 69 | 100 gramP
£ 6. 32 DT = £ 7. 90
▶Dermovate(GlaxoSmithKline UK Ltd)
Clobetasol propionate 500 microgram per 1 gramDermovate
0. 05 % cream| 30 gramP£ 2. 69 DT = £ 2. 69 | 100 gramP
£ 7. 90 DT = £ 7. 90
Ointment
CAUTIONARY AND ADVISORY LABELS 28
EXCIPIENTS:May contain Propylene glycol
▶Clobetasol propionate (Non-proprietary)
Clobetasol propionate 500 microgram per 1 gramClobetasol
0. 05 % ointment| 30 gramPsDT = £ 2. 69 | 100 gramPs
DT = £ 7. 90
▶ClobaDerm(Auden McKenzie (Pharma Division) Ltd)
Clobetasol propionate 500 microgram per 1 gramClobaDerm
0. 05 % ointment| 30 gramP£ 2. 15 DT = £ 2. 69 | 100 gramP
£ 6. 32 DT = £ 7. 90
▶Dermovate(GlaxoSmithKline UK Ltd)
Clobetasol propionate 500 microgram per 1 gramDermovate
0. 05 % ointment| 30 gramP£ 2. 69 DT = £ 2. 69 | 100 gramP
£ 7. 90 DT = £ 7. 90
Liquid
CAUTIONARY AND ADVISORY LABELS15, 28
▶Dermovate(GlaxoSmithKline UK Ltd)
Clobetasol propionate 500 microgram per 1 gramDermovate
0. 05 % scalp application| 30 mlP£ 3. 07 DT = £ 3. 07 |
100 mlP£ 10. 42 DT = £ 10. 42
Combinations available:Clobetasol propionate with neomycin
sulfate and nystatin,p. 742736 Inflammatory skin conditions BNFC 2018 – 2019
Skin13