BNF for Children (BNFC) 2018-2019

TABLE 9

Drugs that prolong the QT interval

The following is a list of some drugs that prolong the QT-interval (note that this list is not exhaustive). In general, manufacturers advise
that the use of two or more drugs that are associated with QT prolongation should be avoided. Increasing age, female sex, cardiac disease,
and some metabolic disturbances (notably hypokalaemia) predispose to QT prolongation—concurrent use of drugs that reduce serum
potassium might further increase this risk (see table of drugs that reduce serum potassium).

Drugs that are not known to prolong the QT interval but are predicted (by the manufacturer) to increase the risk of QT prolongation
include: domperidone, fingolimod, granisetron, ivabradine, mefloquine, mizolastine, palonosetron, and intravenous pentamidine. Most
manufacturers advise avoiding concurrent use with drugs that prolong the QT interval.

amifampridine
amiodarone
amisulpride
anagrelide
apomorphine
arsenic trioxide
artemether
artenimol
bedaquiline
bosutinib
cabozantinib
ceritinib
chlorpromazine
citalopram

clarithromycin

clomipramine

crizotinib

dasatinib

delamanid

disopyramide

dronedarone

droperidol

efavirenz

eribulin

erythromycin

escitalopram

flecainide

fluconazole

fluphenazine

haloperidol

hydroxyzine

inotuzumab ozogamicin

lapatinib

levomepromazine

lithium

lofexidine

methadone

moxifloxacin

nilotinib

ondansetron

osimertinib

paliperidone

panobinostat

pasireotide

pazopanib

pimozide

quinine

ranolazine

ribociclib

risperidone

saquinavir

sildenafil

sorafenib

sotalol

sulpiride

sunitinib

telavancin

tetrabenazine

tizanidine

tolterodine

toremifene

vandetanib

vardenafil

vemurafenib

venlafaxine

vinflunine

voriconazole

zuclopenthixol

TABLE 10

Drugs with antimuscarinic effects

The following is a list of some drugs that have antimuscarinic effects (note that this list is not exhaustive). Concurrent use of two or more
drugs from this list might increase the risk of these effects occurring.

aclidinium
amantadine
amitriptyline
atropine
baclofen
chlorphenamine
chlorpromazine
clemastine
clomipramine
clozapine
cyclizine

cyclopentolate

cyproheptadine

darifenacin

dicycloverine

dimenhydrinate

disopyramide

dosulepin

doxepin

fesoterodine

flavoxate

glycopyrronium

haloperidol

homatropine

hydroxyzine

hyoscine

imipramine

ipratropium

levomepromazine

lofepramine

loxapine

nefopam

nortriptyline

orphenadrine

oxybutynin

perphenazine

pimozide

prochlorperazine

procyclidine

promethazine

propafenone

propantheline

propiverine

solifenacin

tiotropium

tolterodine

trifluoperazine

trihexyphenidyl

trimipramine

tropicamide

trospium

umeclidinium

TABLE 11

Drugs with CNS depressant effects

The following is a list of some drugs with CNS depressant effects (note that this list is not exhaustive). Concurrent use of two or more
drugs from this list might increase the risk of CNS depressant effects, such as drowsiness, which might affect the ability to perform skilled
tasks (see’Drugs and Driving’inGuidance on Prescribingp. 1).

agomelatine
alcohol (beverage)
alfentanil
alimemazine
alprazolam
amisulpride
apraclonidine
aripiprazole
articaine
asenapine
baclofen
benperidol
brimonidine
buclizine
bupivacaine
buprenorphine
cannabis extract
chloral hydrate
chlordiazepoxide
chlorphenamine
chlorpromazine
cinnarizine
clemastine
clobazam

clomethiazole

clonazepam

clonidine

clozapine

codeine

cyclizine

cyproheptadine

desflurane

dexmedetomidine

diamorphine

diazepam

dihydrocodeine

dipipanone

droperidol

etomidate

fentanyl

flupentixol

fluphenazine

flurazepam

gabapentin

guanfacine

haloperidol

hydromorphone

hydroxyzine

isoflurane

ketamine

ketotifen

lamotrigine

levetiracetam

levomepromazine

lidocaine

lofexidine

loprazolam

lorazepam

lormetazepam

loxapine

lurasidone

melatonin

mepivacaine

meprobamate

meptazinol

methadone

methocarbamol

methoxyflurane

mianserin

midazolam

mirtazapine

morphine

moxonidine

nabilone

nitrazepam

nitrous oxide

olanzapine

oxazepam

oxycodone

paliperidone

papaveretum

pentazocine

perampanel

pericyazine

perphenazine

pethidine

phenobarbital

pimozide

pizotifen

pregabalin

prilocaine

primidone

prochlorperazine

promazine

promethazine

propofol

quetiapine

remifentanil

risperidone

ropivacaine

sevoflurane

sodium oxybate

sufentanil

sulpiride

tapentadol

temazepam

tetracaine

thalidomide

thiopental

tizanidine

tramadol

trazodone

trifluoperazine

venlafaxine

zaleplon

zolpidem

zopiclone

zuclopenthixol

BNFC 2018 – 2019 Appendix 1 Interactions 849

Interactions

|Appendix 1

A1