▶Dronedaroneis predicted to increase the exposure toopioids
(alfentanil, buprenorphine, fentanyl, oxycodone). Monitor and
adjust dose.oStudy
▶Amiodaroneis predicted to increase the concentration of
opioids(fentanyl).oTheoretical→Also seeTABLE 6p. 848
▶Dronedaroneis predicted to increase the exposure toopioids
(methadone, sufentanil).oTheoretical→Also seeTABLE 9
p. 849
▶Dronedaroneis predicted to increase the exposure to
oxybutynin.nTheoretical
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
increase the exposure topanobinostat. Adjust dose.o
Theoretical→Also seeTABLE 9p. 849
▶Dronedaroneis predicted to increase the exposure to
pazopanib.oTheoretical→Also seeTABLE 9p. 849
▶Propafenoneis predicted to increase the anticoagulant effect
ofphenindione. Monitor and adjust dose.oTheoretical
▶Dronedaroneis predicted to increase the exposure to
phosphodiesterase type-5 inhibitors(avanafil). Adjustavanafil
dose.oTheoretical
▶Dronedaroneis predicted to increase the exposure to
phosphodiesterase type-5 inhibitors(sildenafil). Monitor or
adjustsildenafildose with moderate inhibitors of CYP3A4,
p. 120.oStudy→Also seeTABLE 9p. 849
▶Dronedaroneis predicted to increase the exposure to
phosphodiesterase type-5 inhibitors(tadalafil).rTheoretical
▶Dronedaroneis predicted to increase the exposure to
phosphodiesterase type-5 inhibitors(vardenafil). Adjust dose.
rTheoretical→Also seeTABLE 9p. 849
▶Dronedaronepotentially increases the exposure to
pibrentasvir.oTheoretical
▶Dronedaroneis predicted to increase the exposure topimozide.
Avoid.rTheoretical→Also seeTABLE 9p. 849
▶Propafenoneis predicted to increase the exposure to
pitolisant. Use with caution and adjust dose.oStudy
▶Dronedaroneis predicted to increase the exposure to
quetiapine. Avoid.oStudy
▶Quinolones(ciprofloxacin)slightly increase the exposure to
lidocaine.nStudy
▶Dronedaroneis predicted to increase the exposure to
ranolazine.rStudy→Also seeTABLE 9p. 849
▶Amiodaroneis predicted to increase the exposure toretinoids
(alitretinoin). Adjustalitretinoindose.oTheoretical
▶Ribociclib(high-dose) is predicted to increase the exposure to
amiodarone. Avoid.oTheoretical→Also seeTABLE 9p. 849
▶Dronedaroneis predicted to increase the exposure to
ribociclib.oStudy→Also seeTABLE 9p. 849
▶Rifampicinis predicted to decrease the exposure to
antiarrhythmics(disopyramide, dronedarone). Avoid.r
Study
▶Rifampicinis predicted to decrease the efficacy ofpropafenone.
oStudy
▶Dronedaroneis predicted to increase the exposure to
rivaroxaban. Avoid.oTheoretical
▶Rolapitantis predicted to increase the exposure to
propafenone.rStudy
▶Dronedaroneis predicted to increase the exposure to
ruxolitinib.oTheoretical
▶Dronedaroneis predicted to increase the exposure to
saxagliptin.nStudy
▶Simepreviris predicted to increase the concentration of
amiodarone. Refer to specialist literature.rAnecdotal
▶Dronedaroneis predicted to increase the exposure to
simeprevir. Avoid.rStudy
▶Amiodaroneis predicted to increase the concentration of
sirolimus.rAnecdotal
▶Dronedaroneincreases the concentration ofsirolimus. Monitor
and adjust dose.oStudy
▶Sofosbuviris predicted to increase the risk of severe
bradycardia or heart block when given withamiodarone. Refer
to specialist literature.rAnecdotal
▶SSRIs(fluvoxamine)are predicted to increase the exposure to
propafenone. Monitor and adjust dose.oStudy
▶Dronedaroneis predicted to increase the exposure toSSRIs
(citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine,
sertraline).rTheoretical→Also seeTABLE 9p. 849
▶Dronedaroneis predicted to increase the exposure toSSRIs
(dapoxetine). Adjustdapoxetinedose with moderate inhibitors
of CYP3A4.oTheoretical
▶St John’sWortis predicted to decrease the exposure to
dronedarone. Avoid.rTheoretical
▶Amiodaroneis predicted to increase the risk of rhabdomyolysis
when given withstatins(atorvastatin). Monitor and adjust
dose.oTheoretical
▶Dronedaroneis predicted to increase the exposure tostatins
(atorvastatin). Monitor and adjust dose.rStudy
▶Amiodaroneis predicted to increase the exposure tostatins
(fluvastatin).rTheoretical
▶Dronedaroneslightly increases the exposure tostatins
(rosuvastatin). Adjust dose.rStudy
▶Amiodaroneincreases the risk of rhabdomyolysis when given
withstatins(simvastatin). Adjustsimvastatindose,p. 134.
rStudy
▶Dronedaroneis predicted to increase the exposure tostatins
(simvastatin). Use with caution and adjustsimvastatindose,
p. 134.rStudy
▶Amiodaroneis predicted to increase the exposure to
sulfonylureas. Use with caution and adjust dose.o
Study
▶Dronedaroneis predicted to increase the exposure tosunitinib.
oTheoretical→Also seeTABLE 9p. 849
▶Lidocaineis predicted to increase the effects of
suxamethonium.oStudy
▶Amiodaroneis predicted to increase the concentration of
tacrolimus.rAnecdotal
▶Dronedaroneis predicted to increase the concentration of
tacrolimus.rStudy
▶Dronedaroneis predicted to increase the exposure totaxanes
(cabazitaxel).oTheoretical
▶Dronedaroneis predicted to increase the exposure totaxanes
(paclitaxel).rTheoretical
▶Dronedaroneis predicted to increase the concentration of
temsirolimus.oTheoretical
▶Theophyllinedecreases the efficacy ofadenosine. Separate
administration by 24 hours.nStudy
▶Amiodaroneis predicted to increase the risk of thyroid
dysfunction when given withthyroid hormones. Avoid.
oStudy
▶Amiodaroneis predicted to increase the exposure toticagrelor.
Use with caution or avoid.rStudy
▶Dronedaroneis predicted to increase the exposure to
tofacitinib.oStudy
▶Dronedaroneis predicted to increase the exposure to
tolterodine.nTheoretical→Also seeTABLE 9p. 849
▶Dronedaroneis predicted to increase the exposure to
tolvaptan. Adjust dose.oStudy
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
increase the exposure totopotecan.rStudy
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
increase the concentration oftrametinib.oTheoretical
▶Dronedaroneis predicted to increase the exposure to
trazodone.oTheoretical
▶Dronedaroneis predicted to increase the exposure totricyclic
antidepressants. Avoid.rTheoretical→Also seeTABLE 9
p. 849
▶Propafenoneis predicted to increase the concentration of
tricyclic antidepressants.oTheoretical→Also seeTABLE 10
p. 849
▶Dronedaroneis predicted to increase the exposure toulipristal.
Avoid if used for uterinefibroids.oStudy
▶Amiodaroneis predicted to increase the concentration of
velpatasvir. Avoid or monitor.oTheoretical
▶Amiodaroneis predicted to increase the exposure to
venetoclax. Avoid or monitor for toxicity.rTheoretical
▶Dronedaroneis predicted to increase the exposure to
venetoclax. Avoid moderate inhibitors of CYP3A4 or adjust
venetoclaxdose.rStudyBNFC 2018 – 2019 Antiarrhythmics—Antiarrhythmics 861
Interactions|Appendix 1A1