Antiarrhythmics(continued)
▶Propafenoneincreases the concentration ofdigoxin. Monitor
and adjust dose.rStudy
▶Dipyridamoleincreases the exposure toadenosine. Avoid or
adjust dose.rStudy
▶Dronedaroneincreases the risk of QT-prolongation when
given withdomperidone. Avoid.rStudy
▶Dronedaroneis predicted to increase the exposure todopamine
receptor agonists(bromocriptine).rTheoretical
▶Dronedaroneis predicted to increase the concentration of
dopamine receptor agonists(cabergoline).rAnecdotal
▶Dronedaroneis predicted to moderately increase the exposure
todutasteride.nStudy
▶Amiodaroneslightly increases the exposure toedoxaban.
rStudy
▶Dronedaroneslightly increases the exposure toedoxaban.
Adjustedoxabandose.rStudy
▶Efavirenzis predicted to decrease the exposure to
dronedarone.rTheoretical→Also seeTABLE 9p. 849
▶Antiarrhythmics(dronedarone, propafenone)are predicted to
increase the exposure toeliglustat. Avoid or adjust dose—
consult product literature.rStudy
▶Enzalutamideis predicted to decrease the exposure to
antiarrhythmics(disopyramide, dronedarone). Avoid.r
Study
▶Enzalutamideis predicted to decrease the efficacy of
propafenone.oStudy
▶Dronedaroneis predicted to increase the risk of ergotism when
given withergometrine.rTheoretical
▶Dronedaroneis predicted to increase the risk of ergotism when
given withergotamine.rTheoretical
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
increase the exposure toerlotinib.oTheoretical
▶Dronedaroneis predicted to increase the concentration of
everolimus. Avoid or adjust dose.oStudy
▶Dronedaroneis predicted to increase the exposure to
fesoterodine. Adjustfesoterodinedose with moderate
inhibitors of CYP3A4 in hepatic and renal impairment.n
Study
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
increase the exposure tofidaxomicin. Avoid.oStudy
▶Dronedaroneis predicted to increase the exposure togefitinib.
oTheoretical
▶Dronedaronepotentially increases the exposure toglecaprevir.
oTheoretical
▶Grapefruit juiceincreases the exposure toamiodarone. Avoid.
oStudy
▶Grapefruit juicemoderately increases the exposure to
dronedarone. Avoid.rStudy
▶Grapefruit juiceincreases the exposure topropafenone.
Monitor and adjust dose.oStudy
▶Dronedaroneis predicted to increase the concentration of
guanfacine. Adjustguanfacinedose,p. 231.oTheoretical
▶H 2 receptor antagonists(cimetidine)increase the exposure to
amiodarone.oStudy
▶H 2 receptor antagonists(cimetidine)slightly increase the
exposure toflecainide. Monitor and adjust dose.nStudy
▶H 2 receptor antagonists(cimetidine)increase the exposure to
lidocaine. Monitor and adjust dose.oStudy
▶H 2 receptor antagonists(cimetidine)are predicted to increase
the exposure topropafenone. Monitor and adjust dose.
oTheoretical
▶HIV-protease inhibitorsare predicted to increase the exposure
toamiodarone. Avoid.rTheoretical→Also seeTABLE 9p. 849
▶HIV-protease inhibitorsare predicted to increase the exposure
todisopyramide.rTheoretical→Also seeTABLE 9p. 849
▶HIV-protease inhibitorsvery markedly increase the exposure to
dronedarone. Avoid.rStudy→Also seeTABLE 9p. 849
▶HIV-protease inhibitorsare predicted to increase the exposure
tolidocaine. Avoid.rStudy
▶HIV-protease inhibitorsare predicted to increase the exposure
topropafenone. Monitor and adjust dose.rStudy
▶Amiodaroneis predicted to increase the exposure toibrutinib.
Adjustibrutinibdose.rTheoretical▶Dronedaroneis predicted to increase the exposure toibrutinib.
Adjustibrutinibdose with moderate inhibitors of CYP3A4.
rStudy
▶Idelalisibis predicted to increase the exposure toamiodarone.
Avoid.oTheoretical
▶Idelalisibvery markedly increases the exposure to
dronedarone. Avoid.rStudy
▶Idelalisibis predicted to increase the exposure topropafenone.
Monitor and adjust dose.rStudy
▶Imatinibis predicted to increase the exposure todronedarone.
rTheoretical
▶Imatinibis predicted to increase the exposure topropafenone.
Monitor and adjust dose.oStudy
▶Dronedaroneis predicted to increase the exposure to
ivabradine. Adjustivabradinedose.rTheoretical
▶Dronedaroneis predicted to increase the exposure toivacaftor.
Adjustivacaftordose with moderate inhibitors of CYP3A4,
p. 186.rStudy
▶Dronedaroneis predicted to increase the exposure tolapatinib.
oStudy→Also seeTABLE 9p. 849
▶Ledipasvirincreases the risk of severe bradycardia or heart
block when given withamiodarone. Refer to specialist
literature.rAnecdotal
▶Amiodaroneis predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.o
Theoretical
▶Dronedaroneis predicted to increase the exposure to
lomitapide. Avoid.oTheoretical
▶Dronedaroneis predicted to increase the exposure to
loperamide.rTheoretical
▶Dronedaroneis predicted to increase the exposure to
lurasidone.oStudy
▶Macrolides(clarithromycin)very markedly increase the
exposure todronedarone. Avoid.rStudy→Also seeTABLE 9
p. 849
▶Macrolides(clarithromycin)are predicted to increase the
exposure topropafenone. Monitor and adjust dose.r
Study
▶Macrolides(clarithromycin, erythromycin)are predicted to
increase the exposure tolidocaine.oTheoretical
▶Macrolides(erythromycin)are predicted to moderately increase
the exposure todronedarone. Avoid.rTheoretical→Also
seeTABLE 9p. 849
▶Macrolides(erythromycin)are predicted to increase the
exposure topropafenone. Monitor and adjust dose.o
Study
▶Dronedaroneis predicted to increase the exposure to
midazolam. Monitor side effects and adjust dose.rStudy
▶Dronedaroneis predicted to increase the exposure to
midostaurin.oTheoretical
▶Mitotaneis predicted to decrease the exposure to
antiarrhythmics(disopyramide, dronedarone). Avoid.r
Study
▶Mitotaneis predicted to decrease the efficacy ofpropafenone.
oStudy
▶Dronedaroneincreases the risk of neutropenia when given
withmonoclonal antibodies(brentuximab vedotin). Monitor and
adjust dose.rTheoretical
▶Dronedaroneis predicted to increase the exposure to
naloxegol. Adjustnaloxegoldose and monitor side effects.
oStudy
▶Netupitantis predicted to increase the exposure to
propafenone. Monitor and adjust dose.oStudy
▶Nevirapineis predicted to decrease the exposure to
dronedarone.rTheoretical
▶Nilotinibis predicted to increase the exposure topropafenone.
Monitor and adjust dose.oStudy
▶Antiarrhythmics(amiodarone, dronedarone)are predicted to
increase the exposure tonintedanib.oStudy
▶NSAIDs(celecoxib)are predicted to increase the exposure to
antiarrhythmics(flecainide, propafenone). Monitor and adjust
dose.oTheoretical
▶Dronedaroneis predicted to increase the exposure toolaparib.
Avoid moderate inhibitors of CYP3A4 or adjustolaparibdose.
oTheoretical860 Antiarrhythmics—Antiarrhythmics BNFC 2018 – 2019
Interactions|Appendix 1A1