Antiepileptics(continued)
▶Carbamazepinepotentially decreases the exposure to
olanzapine. Monitor and adjust dose.oStudy
▶Phenytoinis predicted to decrease the exposure toolanzapine.
Monitor and adjust dose.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toolaparib. Avoid.oTheoretical
▶Carbamazepineis predicted to decrease the exposure to
ombitasvir. Avoid.rTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toondansetron.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toopioids(alfentanil, fentanyl).oStudy→Also see
TABLE 11p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toopioids(buprenorphine). Monitor and adjust dose.o
Theoretical→Also seeTABLE 11p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)decrease the exposure toopioids
(methadone). Monitor and adjust dose.rStudy→Also see
TABLE 11p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toopioids(oxycodone). Monitor and adjust dose.o
Study→Also seeTABLE 11p. 849
▶Carbamazepinedecreases the concentration ofopioids
(tramadol). Adjust dose.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to moderately decrease
the exposure toosimertinib. Avoid.oStudy
▶Oxybutyninpotentially increases the risk of overheating and
dehydration when given withzonisamide. Avoid in children.
rTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
topalbociclib. Avoid.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
topaliperidone. Monitor and adjust dose.rStudy→Also
seeTABLE 11p. 849
▶Valproateslightly increases the exposure topaliperidone.
Adjust dose.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
topanobinostat. Avoid.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)decrease the exposure toparacetamol.
oStudy→Also seeTABLE 1p. 847
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toparitaprevir(with ritonavir and ombitasvir). Avoid.r
Study
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
topazopanib. Avoid.rTheoretical
▶Valproateincreases the risk of side-effects when given with
penicillins(pivmecillinam). Avoid.rAnecdotal
▶Phenothiazines(chlorpromazine)decrease the concentration of
antiepileptics(phenobarbital, primidone)andantiepileptics
(phenobarbital, primidone)decrease the concentration of
phenothiazines(chlorpromazine).oStudy→Also see
TABLE 11p. 849
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tophosphodiesterase type-5 inhibitors(avanafil, tadalafil). Avoid.
rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tophosphodiesterase type-5 inhibitors(sildenafil, vardenafil).
oTheoretical▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to moderately to markedly
decrease the exposure topibrentasvir. Avoid.rStudy
▶Antiepileptics(eslicarbazepine, oxcarbazepine)potentially
decrease the exposure topibrentasvir. Avoid.rTheoretical
▶Antiepileptics(fosphenytoin, phenytoin)are predicted to
decrease the exposure topirfenidone.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to moderately decrease
the exposure topitolisant.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toponatinib. Avoid.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to markedly decrease the
exposure topraziquantel. Avoid.oStudy
▶Antiepileptics(carbamazepine, phenobarbital, phenytoin,
primidone)are predicted to increase the risk of
hypersensitivity reactions when given withprocarbazine.
rAnecdotal
▶Fosphenytoinis predicted to increase the risk of
hypersensitivity when given withprocarbazine.r
Anecdotal
▶Valproatepotentially increases the concentration ofpropofol.
Adjust dose.rTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toquetiapine.oStudy→Also seeTABLE 11p. 849
▶Valproatepotentially increases the risk of neutropenia when
given withquetiapine.oStudy
▶Quinolones(ciprofloxacin)affect the concentration of
antiepileptics(fosphenytoin, phenytoin). Monitor concentration
and adjust dose.rStudy
▶Antiepileptics(fosphenytoin, phenobarbital, phenytoin,
primidone)are predicted to affect the exposure toraltegravir.
Use with caution or avoid.oTheoretical
▶Carbamazepineis predicted to affect the exposure to
raltegravir.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toranolazine. Avoid.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toreboxetine.oAnecdotal
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toregorafenib. Avoid.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
torepaglinide. Monitor blood glucose and adjust dose.
oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to markedly decrease the
exposure toribociclib. Avoid.rStudy
▶Antiepileptics(phenobarbital, primidone)are predicted to
decrease the exposure torifampicinandrifampicinis predicted
to decrease the exposure toantiepileptics(phenobarbital,
primidone). Use with caution and adjust dose.oStudy
▶Rifampicindecreases the concentration ofantiepileptics
(fosphenytoin, phenytoin). Use with caution and adjust dose.
oStudy
▶Rifampicinslightly decreases the exposure tobrivaracetam.
Adjust dose.oStudy
▶Rifampicinmarkedly increases the clearance oflamotrigine.
Adjustlamotriginedose,p. 202.oStudy
▶Rifampicinis predicted to decrease the exposure to
perampanel. Monitor and adjust dose.oStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)markedly decrease the exposure to
rilpivirine. Avoid.rStudy
▶Oxcarbazepineis predicted to decrease the concentration of
rilpivirine. Avoid.rTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure868 Antiepileptics—Antiepileptics BNFC 2018 – 2019
Interactions|Appendix 1A1