▶HIV-protease inhibitorsslightly to moderately increase the
exposure toelbasvir. Avoid.oStudy
▶Idelalisibslightly to moderately increases the exposure to
elbasvir. Avoid.oStudy
▶Macrolides(clarithromycin)slightly to moderately increase the
exposure toelbasvir. Avoid.oStudy
▶Mitotaneis predicted to decrease the exposure toelbasvir.
Avoid.rStudy
▶Modafinilis predicted to decrease the exposure toelbasvir.
Avoid.qTheoretical
▶Nevirapineis predicted to moderately decrease the exposure
toelbasvir. Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure toelbasvir.
Avoid.rStudy
▶St John’s Wortis predicted to moderately decrease the
exposure toelbasvir. Avoid.rStudy
▶Elbasvirpotentially increases the exposure tostatins
(atorvastatin). Adjustatorvastatindose,p. 132.oStudy
▶Elbasviris predicted to increase the exposure tostatins
(fluvastatin). Adjustfluvastatindose,p. 132.qTheoretical
▶Elbasvirincreases the exposure tostatins(rosuvastatin). Adjust
rosuvastatindose,p. 133.oStudy
▶Elbasviris predicted to increase the exposure tostatins
(simvastatin). Adjustsimvastatindose,p. 134.q
Theoretical
▶Elbasviris predicted to increase the concentration ofsunitinib.
Use with caution and adjust dose.oTheoretical
Eletriptan→seeTABLE 13p. 850 (serotonin syndrome)
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to markedly increase the exposure toeletriptan.
Avoid.rStudy
▶Cobicistatis predicted to markedly increase the exposure to
eletriptan. Avoid.rStudy
▶Eletriptanincreases the risk of vasoconstriction when given
withergotamine. Separate administration by 24 hours.r
Study
▶HIV-protease inhibitorsare predicted to markedly increase the
exposure toeletriptan. Avoid.rStudy
▶Idelalisibis predicted to markedly increase the exposure to
eletriptan. Avoid.rStudy
▶Macrolides(clarithromycin)are predicted to markedly increase
the exposure toeletriptan. Avoid.rStudy
▶Macrolides(erythromycin)moderately increase the exposure to
eletriptan. Avoid.oStudy
Eliglustat
▶Abirateroneis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Eliglustatis predicted to increase the exposure toaliskiren.
Adjust dose.oStudy
▶Antiarrhythmics(dronedarone, propafenone)are predicted to
increase the exposure toeliglustat. Avoid or adjust dose—
consult product literature.rStudy
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
toeliglustat. Avoid.rStudy
▶Antifungals, azoles(fluconazole, isavuconazole, itraconazole,
ketoconazole, posaconazole, voriconazole)are predicted to
increase the exposure toeliglustat. Avoid or adjust dose—
consult product literature.rStudy
▶Eliglustatis predicted to increase the exposure to
antihistamines, non-sedating(fexofenadine). Adjust dose.
oStudy
▶Aprepitantis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Eliglustatis predicted to increase the exposure toatomoxetine.
Adjust dose.oTheoretical
▶Eliglustatis predicted to increase the exposure tobeta blockers,
non-selective(propranolol). Adjust dose.oStudy
▶Eliglustatis predicted to increase the exposure tobeta blockers,
selective(metoprolol). Adjust dose.oStudy
▶Bosentanis predicted to decrease the exposure toeliglustat.
oTheoretical
▶Bupropionis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure toeliglustat. Avoid or adjust dose—
consult product literature.rStudy
▶Cinacalcetis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Cobicistatis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Eliglustatis predicted to increase the exposure tocolchicine.
Avoid or adjustcolchicinedose.rTheoretical
▶Crizotinibis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Eliglustatis predicted to increase the exposure todabigatran.
Adjust dose.oStudy
▶Eliglustatincreases the exposure todigoxin. Adjust dose.
oStudy
▶Duloxetineis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Eliglustatis predicted to increase the exposure toedoxaban.
Adjust dose.oStudy
▶Efavirenzis predicted to decrease the exposure toeliglustat.
oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
eliglustat. Avoid.rStudy
▶Eliglustatis predicted to increase the exposure toeverolimus.
Adjust dose.oStudy
▶Grapefruit juiceis predicted to increase the exposure to
eliglustat. Avoid.rTheoretical
▶HIV-protease inhibitorsare predicted to increase the exposure
toeliglustat. Avoid or adjust dose—consult product literature.
rStudy
▶Idelalisibis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Imatinibis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Eliglustatis predicted to increase the exposure toloperamide.
Adjust dose.oStudy
▶Macrolides(clarithromycin, erythromycin)are predicted to
increase the exposure toeliglustat. Avoid or adjust dose—
consult product literature.rStudy
▶Mirabegronis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Mitotaneis predicted to decrease the exposure toeliglustat.
Avoid.rStudy
▶Moclobemideis predicted to increase the exposure to
eliglustat. Avoid or adjust dose—consult product literature.
rTheoretical
▶Netupitantis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Nevirapineis predicted to decrease the exposure toeliglustat.
oTheoretical
▶Nilotinibis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Eliglustatis predicted to increase the exposure to
phenothiazines(perphenazine). Adjust dose.oTheoretical
▶Quinolones(ciprofloxacin)are predicted to increase the
exposure toeliglustat. Avoid or adjust dose—consult product
literature.rTheoretical
▶Rifampicinis predicted to decrease the exposure toeliglustat.
Avoid.rStudy
▶Eliglustatis predicted to increase the exposure tosirolimus.
Adjust dose.oStudy
▶SSRIs(fluoxetine, paroxetine)are predicted to increase the
exposure toeliglustat. Avoid or adjust dose—consult product
literature.rStudy
▶St John’sWortis predicted to increase the exposure to
eliglustat. Avoid.rStudy
▶Eliglustatis predicted to increase the exposure totaxanes
(paclitaxel). Adjust dose.oStudy
▶Terbinafineis predicted to increase the exposure toeliglustat.
Avoid or adjust dose—consult product literature.rStudy
▶Eliglustatis predicted to increase the exposure totolterodine.
Adjust dose.oTheoretical
▶Eliglustatis predicted to increase the exposure totopotecan.
Adjust dose.oStudyBNFC 2018 – 2019 Elbasvir—Eliglustat 915
Interactions|Appendix 1A1