Grapefruit juice(continued)
▶Grapefruit juiceis predicted to increase the exposure to
lurasidone. Avoid.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
naloxegol. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
nilotinib. Avoid.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
olaparib. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
palbociclib. Avoid.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
pazopanib. Avoid.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
phosphodiesterase type-5 inhibitors. Use with caution or avoid.
oStudy
▶Grapefruit juiceincreases the exposure topimozide. Avoid.
rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
ponatinib.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
praziquantel.oStudy
▶Grapefruit juiceis predicted to increase the exposure to
quetiapine. Avoid.rTheoretical
▶Grapefruit juiceis predicted to increase the concentration of
ranolazine. Avoid.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
regorafenib. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
ribociclib. Avoid.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
ruxolitinib.rTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
saxagliptin.nTheoretical
▶Grapefruit juiceincreases the concentration ofsirolimus.
Avoid.oStudy
▶Grapefruit juicemoderately increases the exposure toSSRIs
(sertraline). Avoid.oStudy
▶Grapefruit juiceincreases the exposure tostatins(atorvastatin).
nStudy
▶Grapefruit juiceincreases the exposure tostatins(simvastatin).
Avoid.rStudy
▶Grapefruit juiceis predicted to increase the exposure to
sunitinib. Avoid.oTheoretical
▶Grapefruit juiceincreases the concentration oftacrolimus.
Avoid.rStudy
▶Grapefruit juiceis predicted to increase the concentration of
temsirolimus. Use with caution or avoid.oTheoretical
▶Grapefruit juicemoderately increases the exposure to
ticagrelor.oStudy
▶Grapefruit juiceincreases the exposure totolvaptan. Avoid.
oStudy
▶Grapefruit juiceis predicted to increase the exposure to
ulipristal. Avoid if used for uterinefibroids.oTheoretical
▶Grapefruit juiceis predicted to increase the exposure to
venetoclax. Avoid.rTheoretical
Grass pollen extract
GENERAL INFORMATIONDesensitising vaccines should be
avoided in patients taking beta-blockers (adrenaline might be
ineffective in case of a hypersensitivity reaction) or ACE
inhibitors (risk of severe anaphylactoid reactions).
Grazoprevir
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tograzoprevir. Avoid.rStudy
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to moderately to markedly increase the exposure to
grazoprevir. Avoid.rStudy
▶Bosentanis predicted to markedly decrease the exposure to
grazoprevir. Avoid.rStudy
▶Ciclosporingreatly increases the exposure tograzoprevir.
Avoid.rStudy
▶Cobicistatis predicted to moderately to markedly increase the
exposure tograzoprevir. Avoid.rStudy▶Efavirenzis predicted to markedly decrease the exposure to
grazoprevir. Avoid.rStudy
▶Enzalutamideis predicted to decrease the exposure to
grazoprevir. Avoid.rStudy
▶Etravirineis predicted to decrease the exposure tograzoprevir.
Avoid.nTheoretical
▶HIV-protease inhibitorsare predicted to moderately to
markedly increase the exposure tograzoprevir. Avoid.r
Study
▶Idelalisibis predicted to moderately to markedly increase the
exposure tograzoprevir. Avoid.rStudy
▶Macrolides(clarithromycin)are predicted to moderately to
markedly increase the exposure tograzoprevir. Avoid.r
Study
▶Mitotaneis predicted to decrease the exposure tograzoprevir.
Avoid.rStudy
▶Modafinilis predicted to decrease the exposure tograzoprevir.
Avoid.qTheoretical
▶Nevirapineis predicted to markedly decrease the exposure to
grazoprevir. Avoid.rStudy
▶Rifampicinis predicted to decrease the exposure to
grazoprevir. Avoid.rStudy
▶St John’s Wortis predicted to markedly decrease the exposure
tograzoprevir. Avoid.rStudy
▶Grazoprevirincreases the exposure tostatins(atorvastatin).
Adjustatorvastatindose,p. 132.oStudy
▶Grazopreviris predicted to increase the exposure tostatins
(fluvastatin). Adjustfluvastatindose,p. 132.qTheoretical
▶Grazoprevirincreases the exposure tostatins(rosuvastatin).
Adjustrosuvastatindose,p. 133.oStudy
▶Grazopreviris predicted to increase the exposure tostatins
(simvastatin). Adjustsimvastatindose,p. 134.q
Theoretical
▶Grazopreviris predicted to increase the concentration of
sunitinib. Use with caution and adjust dose.o
Theoretical
▶Grazoprevirincreases the exposure totacrolimus.o
Study
Griseofulvin
▶Alcohol (beverage)potentially causes a disulfiram-like
reaction when given withgriseofulvin.oAnecdotal
▶Antiepileptics(phenobarbital, primidone)decrease the effects of
griseofulvin.oStudy
▶Griseofulvinpotentially decreases the efficacy ofcombined
hormonal contraceptives. For FSRH guidance, see
Contraceptives, interactionsp. 497.rAnecdotal
▶Griseofulvinpotentially decreases the anticoagulant effect of
coumarins.oAnecdotal
▶Griseofulvinpotentially decreases the efficacy ofdesogestrel.
For FSRH guidance, seeContraceptives, interactionsp. 497.
rAnecdotal
▶Griseofulvindecreases the efficacy ofetonogestrel. For FSRH
guidance, seeContraceptives, interactionsp. 497.r
Anecdotal
▶Griseofulvinpotentially decreases the efficacy of oral
levonorgestrel. For FSRH guidance, seeContraceptives,
interactionsp. 497.rAnecdotal
▶Griseofulvinpotentially decreases the efficacy of
norethisterone. For FSRH guidance, seeContraceptives,
interactionsp. 497.rAnecdotal
▶Griseofulvinpotentially decreases the efficacy ofulipristal. For
FSRH guidance, seeContraceptives, interactionsp. 497.r
Anecdotal
Guanethidine→seeTABLE 8p. 848 (hypotension)
▶Amfetamines(dexamfetamine)decrease the effects of
guanethidine.rStudy
▶Benperidolis predicted to decrease the effects ofguanethidine.
oTheoretical→Also seeTABLE 8p. 848
▶Droperidolis predicted to decrease the effects ofguanethidine.
Monitor and adjust dose.oTheoretical→Also seeTABLE 8
p. 848
▶Haloperidolis predicted to decrease the antihypertensive
effects ofguanethidine. Monitor and adjust dose.o
Theoretical→Also seeTABLE 8p. 848926 Grapefruit juice—Guanethidine BNFC 2018 – 2019
Interactions|Appendix 1A1