Netupitant(continued)
▶St John’s Wortis predicted to decrease the exposure to
netupitant.oTheoretical
▶Netupitantis predicted to increase the exposure tostatins
(atorvastatin). Monitor and adjust dose.rStudy
▶Netupitantis predicted to increase the exposure tostatins
(simvastatin). Use with caution and adjustsimvastatindose,
p. 134.rStudy
▶Netupitantis predicted to increase the exposure tosunitinib.
oTheoretical
▶Netupitantis predicted to increase the concentration of
tacrolimus.rStudy
▶Netupitantis predicted to increase the exposure totaxanes
(cabazitaxel).oTheoretical
▶Netupitantis predicted to increase the concentration of
temsirolimus.oTheoretical
▶Netupitantis predicted to increase the exposure totofacitinib.
oStudy
▶Netupitantis predicted to increase the exposure totolterodine.
nTheoretical
▶Netupitantis predicted to increase the exposure totolvaptan.
Adjust dose.oStudy
▶Netupitantis predicted to increase the exposure totrazodone.
oTheoretical
▶Netupitantis predicted to increase the exposure toulipristal.
Avoid if used for uterinefibroids.oStudy
▶Netupitantis predicted to increase the exposure tovenetoclax.
Avoid moderate inhibitors of CYP3A4 or adjustvenetoclax
dose.rStudy
▶Netupitantis predicted to increase the exposure tovinca
alkaloids.rTheoretical
▶Netupitantis predicted to increase the exposure tozopiclone.
Adjust dose.oStudy
Neuromuscular blocking drugs, non-depolarising→seeTABLE 6
p. 848 (bradycardia),TABLE 20p. 851 (neuromuscular blocking effects)
atracurium.cisatracurium.mivacurium.pancuronium.
rocuronium.vecuronium..
▶Anticholinesterases, centrally actingare predicted to decrease
the effects ofneuromuscular blocking drugs, non-depolarising.
oTheoretical→Also seeTABLE 6p. 848
▶Antiepileptics(carbamazepine)are predicted to decrease the
effects of (but acute use increases the effects of)neuromuscular
blocking drugs, non-depolarising(atracurium, cisatracurium,
pancuronium, rocuronium, vecuronium). Monitor and adjust
dose.oStudy
▶Antiepileptics(fosphenytoin, phenytoin)decrease the effects of
(but acute use increases the effects of)neuromuscular blocking
drugs, non-depolarising(atracurium, cisatracurium,
pancuronium, rocuronium, vecuronium).oStudy
▶Clindamycinincreases the effects ofneuromuscular blocking
drugs, non-depolarising.rAnecdotal
▶Corticosteroidsare predicted to decrease the effects of
neuromuscular blocking drugs, non-depolarising.r
Anecdotal
▶Pancuroniumis predicted to increase the risk of cardiovascular
side-effects when given withdigoxin.rAnecdotal
▶Irinotecanis predicted to decrease the effects of
neuromuscular blocking drugs, non-depolarising.o
Theoretical
▶Intravenousmagnesiumincreases the effects ofneuromuscular
blocking drugs, non-depolarising.oStudy
▶Metoclopramideis predicted to increase the effects of
neuromuscular blocking drugs, non-depolarising.o
Theoretical
▶Penicillins(piperacillin)increase the effects ofneuromuscular
blocking drugs, non-depolarising.oStudy
▶SSRIspotentially increase the risk of prolonged
neuromuscular blockade when given withmivacurium.
qTheoretical
Nevirapine
▶Nevirapineis predicted to decrease the exposure to
antiarrhythmics(dronedarone).rTheoretical
▶Nevirapineis predicted to decrease the concentration of
antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)andantiepileptics(carbamazepine,fosphenytoin, phenobarbital, phenytoin, primidone)are
predicted to decrease the concentration ofnevirapine.r
Study
▶Antifungals, azoles(fluconazole)slightly to moderately increase
the exposure tonevirapine.oStudy
▶Nevirapineis predicted to decrease the exposure toantifungals,
azoles(isavuconazole). Avoid.rTheoretical
▶Nevirapinemoderately decreases the exposure toantifungals,
azoles(itraconazole). Avoid and for 14 days after stopping
nevirapine.oStudy
▶Nevirapinemoderately decreases the exposure toantifungals,
azoles(ketoconazole). Avoid.rStudy
▶Nevirapineis predicted to decrease the exposure toantifungals,
azoles(voriconazole)andantifungals, azoles(voriconazole)
increase the exposure tonevirapine. Monitor and adjust dose.
rTheoretical
▶Nevirapineis predicted to decrease the exposure toaxitinib.
oTheoretical
▶Nevirapineis predicted to decrease the exposure to
bedaquiline. Avoid.rStudy
▶Nevirapineis predicted to decrease the exposure tobosutinib.
Avoid.rTheoretical
▶Nevirapineis predicted to decrease the exposure to
cabozantinib.oTheoretical
▶Nevirapineis predicted to decrease the exposure tocalcium
channel blockers(amlodipine, felodipine, lacidipine,
lercanidipine, nicardipine, nifedipine, nimodipine). Monitor and
adjust dose.oTheoretical
▶Nevirapineis predicted to decrease the exposure tocalcium
channel blockers(diltiazem, verapamil).oTheoretical
▶Nevirapineis predicted to decrease the concentration of
caspofungin. Adjust dose.oTheoretical
▶Nevirapineis predicted to decrease the concentration of
ciclosporin.oStudy
▶Nevirapineis predicted to decrease the exposure tocobicistat.
Avoid.rTheoretical
▶Nevirapineis predicted to decrease the exposure to
cobimetinib. Avoid.rTheoretical
▶Nevirapineis predicted to decrease the efficacy ofcombined
hormonal contraceptives. For FSRH guidance, see
Contraceptives, interactionsp. 497.rStudy
▶Nevirapinepotentially alters the anticoagulant effect of
coumarins.rAnecdotal
▶Nevirapineis predicted to decrease the exposure tocrizotinib.
Avoid.rTheoretical
▶Nevirapineis predicted to decrease the exposure to
daclatasvir. Avoid.rTheoretical
▶Nevirapineis predicted to decrease the exposure todasatinib.
rStudy
▶Nevirapineis predicted to decrease the efficacy ofdesogestrel.
For FSRH guidance, seeContraceptives, interactionsp. 497.
rTheoretical
▶Nevirapinedecreases the exposure todolutegravir. Adjust
dose.rStudy
▶Nevirapinedecreases the concentration ofefavirenz. Avoid.
rStudy
▶Nevirapineis predicted to moderately decrease the exposure
toelbasvir. Avoid.rStudy
▶Nevirapineis predicted to decrease the exposure toeliglustat.
oTheoretical
▶Nevirapineis predicted to decrease the concentration of
elvitegravir. Avoid.rTheoretical
▶Nevirapineis predicted to decrease the effects ofergotamine.
oTheoretical
▶Nevirapineis predicted to decrease the exposure toerlotinib.
rTheoretical
▶Nevirapineis predicted to decrease the efficacy ofetonogestrel.
For FSRH guidance, seeContraceptives, interactionsp. 497.
rTheoretical
▶Nevirapineis predicted to decrease the exposure toetravirine.
Avoid.rStudy
▶Nevirapineis predicted to decrease the concentration of
everolimus. Avoid or adjust dose.rStudy
▶Nevirapineis predicted to decrease the exposure togefitinib.
Avoid.rTheoretical962 Netupitant—Nevirapine BNFC 2018 – 2019
Interactions|Appendix 1A1