Medical Microbiology

ImmunologicalTestMethods 135

Table2. 13 ImportantCDAntigens

Designation
(alternatives)

Cellswhichexpressthe antigen

Functions

CD1 Corticalthymocytes,
Langerhanscells,dendritic
cells,Bcells,intestinal
epithelium

MHCclassI-likemolecule,asso- ciatedwithb 2 microglobulin. Possiblespecialsignificancein specializedantigenpresentation

CD2(LFA-2) Tcells,thymocytes,natural
killercells

Adhesionmoleculewhichbinds toCD58(LFA-3)andcanactivate Tcells(LFA=lymphocytefunc- tionantigen)

CD3 Thymocytes,Tcells Associatedwiththeantigen
receptorofTcells,andisneces-
saryforT-cellreceptorsurface
expressionandsignaltransduc-
tion

CD4 Severalgroupsofthymocytes,
Thelpercells,andinflamma-
toryTcells(abouttwo-thirds
oftheperipheralTcells),
monocytes,macrophages

Co-receptorforMHCclassII molecules.Bindssignaltrans- ducersviacytoplasmicportion. Receptorforgp1 20 inHIV-1 andHIV-2

CD5 Thymocytes,Tcells,
asubgroupofBcells

BindstoCD72

CD8 Severalgroupsofthymocytes,
cytotoxicTcells(aboutone-
thirdoftheperipheralTcells)

Co-receptorforMHCclassI molecules,bindssignaltrans- ducerviacytoplasmicportion

CD1 0 BandTprecursorcells,bone
marrowstromacells

Zincmetalproteinase,andmar- kerforacutelymphoidleukemia ofpre-Bcells

CD11a(achain) Lymphocytes,granulocytes,
monocytes,andmacrophages

asubunitofb 2 integrinLFA-1 (associatedwithCD18).Bindsto CD54(ICAM-1),CD1 02 (ICAM-2), andICAM-3(CD50)

CD1 9 Bcells FormsacomplexwithCD2 1
(CR2)andCD8 1 (TAPA-1),
Co-receptorforBcells

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