Fundamentals of Medicinal Chemistry

Polysaccharide chains Polysaccharide chains NH CO NH NH CO NH CO CO NH NH NH CO NH NH CO CO NHCO NH CO CO NAG NAG NAG NAG NAG NA ...

Key: A = Abequose G = D-Galactose H = Heptose K = 2-Keto-3-deoxyoctanoate (KDO) M = Mannose N = N-Acetylglucosamine (NAG) P = Ph ...

A.3 Cell membranes Cells are broadly classified as eitherprokaryotesoreukaryotes. Prokaryotic cells are found in simpler organis ...

S CH 2 CH COOCH 3 Protein chain of an anchored protein Integral proteins forming Peripheral protein an ion channel Cholesterol P ...

A.4 Receptors Receptors are specific areas of certain proteins and glycoproteins that are found either spanning cellular membran ...

Table A4.1 Superfamilies of receptors. Superfamily General notes concerning their action Type 1 Opens ion channels. Type 2 Bindi ...

However, when the concentration of the drug in the extracellular fluid falls, the equilibrium will move to the left and the drug ...

A.5 Transfer through membranes Substances are transported through membranes by osmosis, filtration, passive diffusion, facilitat ...

A.6 Regression analysis In medicinal chemistry, it is often desirable to obtain mathematical relationships in the form of equati ...

The value of 100r 2 is a measure of the percentage of the data that can satisfactorily explained by the regression analysis. For ...

A.7 Enzymes Enzymes are large protein molecules (apoenzymes), which act as catalysts for almost all the chemical reactions that ...

Table A7.1 The classification of enzymes Code Classification Type of reaction catalysed 1 Oxidoreductases Oxidations and reducti ...

Energy Substrate TS Product Reaction ordinate E−S complex E−P complex TS 1 TS 2 TS 3 Uncatalysed reaction energy changes Enzyme ...

A.8 Prostaglandins The prostaglandins are a group of naturally occurring compounds whose molecular structures are based on that ...

A.9 Cancer Cancer is a disease that can occur in all types of body tissue. It is found in many forms, including solid tissue for ...

A.10 Viruses Viruses are not classified as living organisms since they require the use of the host cell’s biological system in o ...

RNA (or DNA) core Cell binding protein Capsomers RNA (or DNA) core Cell binding protein Lipoprotein envelope (a) (b) Capsomers F ...

A.11 Blood–brain barrier The blood vessels that carry substances around the body are lined with so called endothelial tissue mad ...

A.12 Enzyme structure and species The structure of a specific enzyme may vary from species to species. These differences, which ...

Answers to Questions Numerical answers may be slightly different from the ones you obtain due to differences in calculating meth ...