9780521516358book.pdf

of a dynamic interacting system. This has led to the development of the concept of

systems biology, which can be defined as the study of living organisms in terms

of their underlying network structure rather than just their individual molecular

components. Since systems biology requires a study of all interacting components

in the cell the new high throughput and quantitative.

8.6 Suggestions for further reading

Cutler, P. (2004).Protein Purification Protocols. Totowa, NJ: Humana Press. (Detailed theory and

practical procedures for a range of protein purification techniques.)

Walker, J. M. (2005).Proteomics Protocols Handbook. Totowa, NJ: Humana Press. (Theory and

techniques of a spectrum of methods applied to proteomics.)

Nedelkov, D. (2006).New and Emerging Proteomics Techniques. New York: Humana Press.

(In-depth details of a range of proteomics techniques.)

Thompson, J. D. (2008).Functional Proteomics. New York: Humana Press. (Comprehensive

coverage of functional proteomics including protein analysis and mass spectrometry.)

Simpson, R. J., Adams, P. D. and Golemis, E. A. (2008).Basic Methods in Protein Purification and

Analysis: A Laboratory Manual. New York: CSH Press. (A comprehensive collection of protein

purification methods.)

20

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18

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110

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101

27

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52

27 47

30

38

29

19

36

25

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77 97

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18 23

(^1839)
16
31
136 32
Amino acid metabolism (23/68)
Carbohydrate metabolism
(30/78)
Cell cycle control
(90/113)
Cell polarity (54/52)
Cell stress (27/75)
Cell structure (39/54)
Chromatin/chromosome
structure (72/102)
Cytokinesis (18)
DNA repair (37/65)
DNA synthesis (41/50)
Differentiation
(4/20)
Lipid/fatty acid and
sterol metabolism (18/27)
Mating response
(41/66)
Meiosis (17/55)
Membrane fusion (23/21) Mitosis (81/75)
Nuclear–cytoplasmic transport
(106/56)
Pol I transcription (9/17)
Pol II transcription (184/177)
Pol III transcription (14/21)
Protein degradation (77/84)
Protein folding (18/32)
Protein
modification
(28/65)
Protein synthesis (54/89)
Protein translocation (51/54)
RNA processing/modification
(117/132)
RNA splicing (65/65)
RNA turnover
(9/16)
Recombination (9/28)
Signal transduction (42/66)
Vesicular transport (141/141)
Fig. 8.10A simplification of Fig. 8.9 identifying interactions between functional groups of proteins (see text for
details). (Courtesy of Benno Schwikowski, Peter Uetz and Stanley Fields. Reprinted with the permission of
Nature Publishing Group.) (See also colour plate.)
351 8.6 Suggestions for further reading