Medicinal Chemistry

a remarkable number of enzymes, most of which are involved in amino acid metabolism. By forming a Schiff base, pyridoxal phospha ...

Biotin deficiency can be triggered only experimentally, using diets rich in raw egg white. The latter contains avidin, a 70 kD p ...

totally unnecessary and without benefit. Some patients with inflammatory bowel diseases, such as Crohn’s disease, may experience ...

milk, and eggs contain vitamin A itself, a cleavage product of β-carotene. It is necessary for the growth of young animals since ...

8.2.8.10 Vitamin D (Calciferol) Vitamin D (8.57, calciferol) is found in fish-liver oils and milk. It is also produced in human ...

Because of the importance of osteoporosis, the area of vitamin D research has become exceptionally active in the generally quies ...

In the absence of the vitamin, the blood-clotting time increases, since the post-translational carboxylation of several glutamat ...

Patient 2. This 68-year-old malnourished chronic alcoholic was found wandering in a state of confusion and disorientation. In th ...

(PrPSCprotein), Parkinson’s disease (α-synuclein), Pick’s disease (tau), Huntington’s disease (polyglutamine-containing protein) ...

Like any other protein, the molecular structure of the prion is subject to conformational flexibility and to various thermal-ind ...

8.3.2.1 Fish Antifreeze Proteins and Drug Design Antifreeze proteins are a group of unique macromolecules that prevent marine bo ...

amino acid composition. These proteins hydrogen-bond to the prism face of ice crystals, inhibiting crystalline growth. These pep ...

agent. Analogs of purines and pyrimidines have been used for other applications as well. For example, analogs of uracil have bee ...

a variety of analogs have been prepared and evaluated. Ribozyme-based drugs may in theory be used against a diversity of disorde ...

8.5.1 Prostaglandins and Thromboxanes 8.5.1.1 Prostaglandins: Structure and Biosynthesis The biosynthesis of prostaglandins and ...

Figure 8.9 Prostaglandins and leukotrienes are potent eicosanoid lipid mediators, derived from phospholipase-released arachidoni ...

8.5.1.2 Prostaglandins: Pharmacological Effects The pharmacological effects of the prostaglandins and TXA 2 comprise many differ ...

Vasodilation and Constriction. PGE 2 and especially PGI 2 (prostacyclin) are powerful, short-acting vasodilators, probably invol ...

however, correlation of these values with the activation of adenylate cyclase is not very convincing. Prostaglandin receptors ha ...

NSAIDs: Non-selective cyclo-oxygenase inhibitors a. Arylanthranilic acids (mefenamic acid, meclofenamate) b. Arylbutyric acids ...