Medicinal Chemistry

(Jacob Rumans) #1

breast cancer, estrogen dependent, 325
bremazocine, 357
bretylium, 227
bromide therapy, 118
bromination of alkenes, 171
bromocriptine, 243
bronchitis, 233
bronchoconstriction, 523
bronchodilation, 523
brotizolam, 275
buformin, 368
bufotenin, 254
bungarotoxin, 487
bupivacaine, 417
buprenorphine, 359
bupropion, 241
burimamide, 267
busulfan, 448–450
butorphanol, 359
butterfly angle, 55–56
butylbarbital, 150
butyrophenones, 244
butyrylcholinesterase, 487


C cells, 360
C-type natriuretic peptide, 377
cabergoline, 248
caffeine, 298
Cahn-Ingold-Prelog rules, 37, 40, 476
calciferol, 510–511
calcitonin, 360, 363
calcitriol, 511
calcium carbonate, 537
calcium channel blockers, 380
calcium channels, 379, 380, 424–430
calcium citrate, 537
calcium gluconate, 537
calcium salts, 536
camphor, 474
camptothecins, 452
cancellous bone, 536
cancer treatment, 459–463
candesartan, 376
Cannizzaro reaction, 172
capecitabine, 451, 452
capsid, 547
captopril, 18, 373, 374, 375, 535
carbachol, 210
carbamate metabolism, 151
carbamazepine, 16, 35, 56, 101, 102,
149, 161, 279, 422, 430
carbamazole, 363
carbaryl, 490
carbenicillin, 567
carbenoxolone, 269


carbidopa, 240
carbocycles, 477
carbohydrates, 474–477
as drugs and targets, 528–529
bioactivity and stereochemistry of, 475–476
types of, 476–477
carbohydromimetic chemistry, 115
carbon monoxide, 291
carbonic anhydrase, as a target, 494–496
carbonic anhydrase inhibitors, 379, 484, 495–496
carboplatin, 454, 456
carboprost, 524
carboxylic acid metabolism, 151
carcinoma, 460
cardenolides, 493
cardiac glycosides, 435
cardiac steroids, 493
cardiodigin, 494
carmustine, 448–450
β-carotene, 474
carvone, 474
caspases, 499, 500–503
catalytic proteins, 467
catalytic RNA, 518
catechol ring, 231
catecholamine metabolism, 226–228
catecholamines, 218
caudate nucleus, 200
CDCA, 316
CDKs, 500
cefazolin, 568
cefotaxime, 568
celecoxib, 525, 526
cell-cycle-specific agents, 456
cell-mediated immunity, 391
cellular process control, 310
central dogma of molecular genetics, 470
cephalexin, 568
cephalins, 472
cephaloridine, 568
cephalosporins, 18, 567–568
cephalothin, 568
cerebellar peduncles, 201
cerebellum, 198
cerebral cortex, 200, 201
cerebral hemorrhage, 379
cerebral infarction, 379
cerebral ischemia, 317
cerebral spinal fluid, 201
cerebrum, 198–200
ceristat, 287
cerivastatin, 318
Chaga’s disease, 584
chaperone peptides, 313
charge transfer interactions, 72

632 INDEX

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