Medicinal Chemistry

metals, 480–481
main group, 480
transition, 480
metastasis, 457, 461
metazocine, 357
metformin, 367, 368
methacholine, 210
methacycline, 573
methadone, 138
methallenestril, 322
methandrostenolone, 329
methestrol, 322
methicillin, 566
methimazole, 551, 363
methotrexate, 14, 157, 161, 393
methoxamine, 229
methoxyphenamine, 231
methyldopa, 14, 225
7 α-methyl-19-nortestosterone, 329
methylprednisolone, 334
methyltyrosine, 240
metiamide, 267
metoprolol, 14, 102
metrifonate, 589
metronidazole, 18, 269
miacalcin, 363
mibefradil, 425, 426
Michael reaction, 168
miconazole, 583–584
microglial cells, 195
microtubules, 440, 454
midazolam, 275
middle cerebral artery, 202
mifepristone, 328
miglitol, 367, 369
migraine, 258, 259
milrinone, 439
Minamata disease, 594
mineralocorticoids, 311, 312
mini-pill, 327
minocycline, 18, 573
minor groove, DNA, 441, 443–446
Minot, 507
minoxidil, 381, 424
misoprostol, 269, 524
mitochondria, 408, 439, 440
mitogen-activated protein kinases, 500
mitosis, 454
mix and split synthesis, 125
mizoribine, 394
MK-801, 285
MM2 calculations, 48
mobile receptor model, 87, 89, 90
moexipril, 375
molecular baggage, 19, 107

molecular dynamics, 49–50

molecular mechanics, 46–49

molecular mimicry, 404

molecular orbital calculations, 45–46

molecular symbiont, 465

monoamine oxidase, 220, 253, 486, 497–499

as a target, 497–499

monocytes, 390

Monod, 484

monosaccharide, 475

monoterpenes, 474

monotherapy, 380

Monte Carlo methods, 49

montelukast, 527

morning-after pill, 328

morphinans, 356

morphine, 14, 18, 137, 354–358, 531

synthetic analogues, 356

morphine-6-methylether, 355

morphinone, 355

mossy fibre sprouting, 432

motion sickness, 265

moxalactam, 568

MPTP, 247

mRNA, 471

multiphore, 8, 106

multiple minima problem, 50–52

multiple myeloma, 447

multiple sclerosis, 397

multiple targets-one disease, 378

muscarine, 38, 206

muscarinic receptors, 205, 209

muscarone, 210

muscimol, 273

myasthenia gravis, 388, 488–489

mycophenolate mofetil, 394

mycotic infections, 581

myelin, 472

myocardial infarction, 8, 379

myocardial ischemia, 317

myoglobin, 479

myosin, 426, 467

myosis, 490

myxedema, 361

Na+/K+ATPase, 434–439

nabilone, 258

nabumetone, 525

nafamostat, 457

nafarelin, 342

naftifine, 584

nalorphine, 358

naloxone, 358

naltrexone, 358

nandrolone, 329

INDEX 641