A Textbook of Clinical Pharmacology and Therapeutics

inflammatory process in inflammatory arthritis. Their mech- anisms are generally poorly understood. They are used in patients wi ...

Stomatitis suggests the possibility of neutropenia. Diarrhoea is uncommon, but goldcolitis is life- threatening. Pharmacokinet ...

(acute gout), cause chalky deposits (tophi) and cause renal stones and/or renal tubular obstruction. The final enzymatic reactio ...

Pharmacokinetics Allopurinolis well absorbed. Hepatic metabolism yields oxy- purinol, itself a weak xanthine oxidase inhibitor. ...

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PART IV THE CARDIOVASCULAR SYSTEM ...

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●Introduction 177 ●Pathophysiology 177 ●Prevention of atheroma 179 ●Drugs used to treat dyslipidaemia 180 CHAPTER 27 PREVENTION ...

in bile into the intestine, where they are involved in fat absorp- tion. The rate-limiting enzyme in cholesterol biosynthesis is ...

responsible for the strong predilection for certain sites (e.g. at the low-shear side of the origin of arteries branching from t ...

Mechanism of action HMG CoA reductase is the rate-limiting step in cholesterol biosynthesis. Statins inhibit this enzyme, loweri ...

DRUGSUSED TOTREATDYSLIPIDAEMIA 181 Dietary fat Bile acid Fat Muscle Fat Muscle FFA FFA Lipoprotein lipase Lipoprotein lipase Liv ...

Adverse effects and contraindications Mild and infrequent side effects include nausea, constipation, diarrhoea, flatulence, fati ...

reduced). The risk of muscle damage is increased if they are taken with a statin, although lipid specialists sometimes employ th ...

Feher MD, Richmond W. Lipids and lipid disorders. London: Gower Medical Publishing, 1991. Hansson GK. Mechanisms of disease: inf ...

●Introduction 185 ●Pathophysiology and sites of drug action 185 ●General principles of managing essential hypertension 187 ●Drug ...

Cardiac output may be increased in children or young adults during the earliest stages of essential hypertension, but by the tim ...

(e.g. co-existing angina) to choose a B drug. Older people and people of Afro-Caribbean ethnicity often have a low plasma renin ...

peptides, such as bradykinin. Angiotensin II causes aldos- terone secretion from the zona glomerulosa of the adrenal cor- tex an ...

AT 1 receptor) produce good 24-hour control. Their beneficial effect in patients with heart failure (Chapter 31) or following my ...