A Textbook of Clinical Pharmacology and Therapeutics

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A Textbook of Clinical Pharmacology and Therapeutics ...

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A Textbook of Clinical Pharmacology and Therapeutics FIFTH EDITION JAMES M RITTERMA DPHIL FRCP FMedSciFBPHARMACOLS Professor of ...

First published in Great Britain in 1981 Second edition 1986 Third edition 1995 Fourth edition 1999 This fifth edition published ...

This fifth edition is dedicated to the memory of Professors Howard Rogers and John Trounce, two of the three authors of this tex ...

COMPANION WEBSITE The fifth edition of A Textbook of Clinical Pharmacology and Therapeuticsis accompanied by an exciting new web ...

CONTENTS FOREWORD viii PREFACE ix PART I GENERAL PRINCIPLES ACKNOWLEDGEMENTS x 1 Introduction to therapeutics 2 Mechanisms of d ...

John Trounce, who was the senior author of the first edition of this textbook, died on the 16 April 2007. He considered a text i ...

Clinical pharmacology is the science of drug use in humans. Clinicians of all specialties pre- scribe drugs on a daily basis, an ...

We would like to thank many colleagues who have helped us with advice and criticism in the revision and updating of this fifth e ...

PART I GENERAL PRINCIPLES ...

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●Use of drugs 3 ●Adverse effects and risk/benefit 3 ●Drug history and therapeutic plan 4 ●Formularies and restricted lists 4 ●Sc ...

5.the best that can reasonably be hoped for in this individual patient; 6.the patient’s beliefs and goals. DRUG HISTORY AND THER ...

and acquired factors, notably disease of the organs responsible for drug metabolism and excretion. Pharmacokinetic modelling is ...

●Introduction 6 ●Receptors and signal transduction 6 ●Agonists 7 ●Antagonism 8 ●Partial agonists 9 ●Slow processes 9 ●Non-recept ...

AGONISTS 7 Receptors were originally classified by reference to the relative potencies of agonists and antagonists on preparatio ...

8 MECHANISMS OF DRUG ACTION(PHARMACODYNAMICS) ANTAGONISM Competitive antagonists combine with the same receptor as an endogenous ...

SLOWPROCESSES 9 The relationship between the concentration of a competi- tive antagonist [B], and the dose ratio (r) was worked ...