A Textbook of Clinical Pharmacology and Therapeutics

90 INTRODUCTION OF NEW DRUGS AND CLINICAL TRIALS Patient groups who respond more or less well may be identi- fied, patient expos ...

GLOBALIZATION 91 ETHICS COMMITTEES Protocols for all clinical trials must be reviewed and approved by a properly constituted ind ...

CHAPTER 16 CELL-BASED AND RECOMBINANT DNA THERAPIES ●Gene therapy 94 ●Human stem cell therapy 95 The term ‘biotechnology’ encomp ...

CELL-BASED ANDRECOMBINANTDNA THERAPIES 93 soluble insulin, a real advance for some patients (see Chapter 37). Other ‘designer’ i ...

94 CELL-BASED AND RECOMBINANTDNATHERAPIES Table 16.4:Prevalence of some genetic disorders which result from a defect in a single ...

HUMANSTEMCELLTHERAPY 95 duration and benefit. Adenoviral vectors are more efficient than liposomes but themselves cause serious ...

96 CELL-BASED AND RECOMBINANTDNATHERAPIES potential than adult stem cells for research and possible therapy. The Gene Therapy Ad ...

●Introduction 97 ●Garlic 97 ●Ginseng 98 ●Ginkgo biloba 99 ●Echinacea 99 ●Soy 99 ●Saw palmetto 100 ●St John’s wort 100 ●Glucosami ...

cell anaemia. Garlic can alter blood coagulability by decreas- ing platelet aggregation and increasing fibrinolysis. Adverse eff ...

A case report has suggested a possible interaction between ginseng consumption and warfarin, but animal studies do not support t ...

possible side effects of traditional hormone replacement ther- apy. The principal constituents of soy, the isoflavones genis- te ...

including hypericin and pseudohypericin. With regard to the putative antidepressant effects of St John’s wort, the phar- macolog ...

FURTHER READING AND WEB MATERIAL Ernst E. A systematic review of systematic reviews of homeopathy. British Journal of Clinical P ...

PART II THE NERVOUS SYSTEM ...

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●Introduction 105 ●Sleep difficulties and insomnia 105 ●Anxiety 107 CHAPTER 18 HYPNOTICS AND ANXIOLYTICS INTRODUCTION Hypnotics ...

depression; anxiety. Much chronic insomnia is due to dependence on hypnotic drugs. In addition, external factors such as noise ...

and daytime sleeping should be discouraged. Increased daytime exercise improves sleep at night. Alcohol should be avoided becau ...

short-term use, as it causes intense withdrawal phenomena and dependence. Diazepamormidazolami.v. before procedures such as end ...

BENZODIAZEPINES VS. NEWER DRUGS Since the advent of the newer non-benzodiazepine hypnotics (zopiclone,zolpidemandzaleplon), ther ...