A Textbook of Clinical Pharmacology and Therapeutics

●Schizophrenia 110 ●Behavioural emergencies 114 CHAPTER 19 SCHIZOPHRENIA AND BEHAVIOURAL EMERGENCIES SCHIZOPHRENIA INTRODUCTION ...

SCHIZOPHRENIA 111 Figure 19.2 shows a summary of putative pathways for the development of schizophrenia. GENERAL PRINCIPLES OF M ...

112 SCHIZOPHRENIA AND BEHAVIOURAL EMERGENCIES DRUGS USED IN TREATMENT CONVENTIONAL ANTIPSYCHOTIC DRUGS The principal action of t ...

The Boston Collaborative Survey indicated that adverse reactions are most common in patients receiving high doses, and that they ...

114 SCHIZOPHRENIA AND BEHAVIOURAL EMERGENCIES that atypical antipsychotics should be considered in newly diagnosed schizophrenic ...

BEHAVIOURALEMERGENCIES 115 a vailability of flumazenilif (particularly i.v.) benzodiazepines are used. FURTHER READING Anon. Whi ...

●Depressive illnesses and antidepressants 116 ●Lithium, tryptophan and St John’s wort 121 ●Special groups 122 CHAPTER 20 MOOD DI ...

DEPRESSIVEILLNESSES ANDANTIDEPRESSANTS 117 e.g. interpersonal difficulties or other life stresses (including physical illness), ...

118 MOOD DISORDERS 3.Epilepsy can be precipitated. 4.They are usually non-sedating, but may cause insomnia and do not usually ca ...

DEPRESSIVEILLNESSES ANDANTIDEPRESSANTS 119 Imipramineandamitriptyline(tertiary amines) have more powerful anticholinergic and ca ...

120 MOOD DISORDERS Lofepramine– less sedative, and with less cardiac toxicity, but occasionally hepatotoxic. Mirtazapine– increa ...

LITHIUM, TRYPTOPHAN AND ST JOHN’S WORT LITHIUM Althoughlithiumis widely used in affective disorders, it has a low toxic to thera ...

ST JOHN’S WORT St John’s wort (Hypericum perforatum) is an unlicensed herbal remedy in popular use for treating depression (Chap ...

SPECIALGROUPS 123 Case history A 45-year-old man with agoraphobia, anxiety and depres- sion associated with hypochondriacal feat ...

PARKINSON’S SYNDROME AND ITS TREATMENT PATHOPHYSIOLOGY James Parkinson first described the tremor, rigidity and bradykinesia/aki ...

PARKINSON’SSYNDROME AND ITSTREATMENT 125 PRINCIPLES OF TREATMENT IN PARKINSONISM Idiopathic Parkinson’s disease is a progressive ...

126 MOVEMENT DISORDERS AND DEGENERATIVE CNS DISEASE involuntary movements (dystonic reactions) – these include akathisia (abnor ...

PARKINSON’S SYNDROME AND ITS TREATMENT 127 pulmonary, retroperitoneal and pericardial fibrotic reactions have been associated w ...

128 MOVEMENT DISORDERS AND DEGENERATIVE CNS DISEASE Adverse effects These include the following: dry mouth, blurred vision, con ...

cervical dystonia (torticollis), jaw-closing oromandibular dysto- nia and adductor laryngeal dysphonia. Botulinum A toxin is giv ...